Pediatric Central Nervous System (CNS) tumors are the most fatal cancer diseases in
childhood. Due to their localization and infiltrative nature, some tumor resections or biopsies …

Background Central nervous system tumors are the most common pediatric solid tumors and
the most frequent cause of cancer-related morbidity in childhood. Significant advances in …

Background The ability to identify genetic alterations in cancers is essential for precision
medicine; however, surgical approaches to obtain brain tumor tissue are invasive. Profiling …

Background Brain cancer is the leading cause of cancer-related death in children. Early
detection and serial monitoring are essential for better therapeutic outcomes. Liquid biopsy …

Malignant primary brain tumors are the most common cancer in children aged 0–14 years,
and are the most common cause of death among pediatric cancer patients. Compared to …

The increased integration of molecular alterations to define tumor type or grade in central
nervous system (CNS) tumor classification brings new challenges for the pathologist to …

OBJECTIVE Primary brain tumors are the most common cause of cancer-related deaths in
children and pose difficult questions for the treating physician regarding issues such as the …

Central nervous system (CNS) tumors are the most common solid tumors in children, and
the leading cause of cancer-related death. Over the past decade, molecular profiling has …

Background Liquid biopsies do not reflect the complete mutation profile of the tumor but
have the potential to identify actionable mutations when tumor biopsies are not available as …

Molecular profiling of childhood CNS tumors is critical for diagnosis and clinical
management, yet tissue access is restricted due to the sensitive tumor location. We …