Diphenyl diselenide protects endothelial cells against oxidized low density lipoprotein-induced injury: involvement of mitochondrial function
MA Hort, MR Straliotto, J de Oliveira, ND Amoêdo… - Biochimie, 2014 - Elsevier
Elevated levels of oxidized low density lipoprotein (oxLDL) are considered to be one of the
major risk factors for atherosclerosis and cardiovascular morbidity. The early stages of …
major risk factors for atherosclerosis and cardiovascular morbidity. The early stages of …
[HTML][HTML] Diphenyl diselenide modulates oxLDL-induced cytotoxicity in macrophage by improving the redox signaling
It has been reported that oxidized LDLs (oxLDL) are involved in the pathogenesis of
atherosclerosis, and that macrophages as well as other cells of the arterial wall can oxidize …
atherosclerosis, and that macrophages as well as other cells of the arterial wall can oxidize …
Diphenyl diselenide effectively reduces atherosclerotic lesions in LDLr−/− mice by attenuation of oxidative stress and inflammation
MA Hort, MR Straliotto, PM Netto… - Journal of …, 2011 - journals.lww.com
Glutathione peroxidase (GPx) plays an important role in the antioxidant defense of the
vascular wall, and its deficiency has been implicated in the development of atherosclerotic …
vascular wall, and its deficiency has been implicated in the development of atherosclerotic …
Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro
Oxidative modification of low-density lipoprotein (LDL) represents an important factor in
atherogenesis. In the present study, we have investigated the antioxidant capability of …
atherogenesis. In the present study, we have investigated the antioxidant capability of …
Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways
The early stages of the atherosclerotic process are initiated by accumulation of oxidized low-
density lipoprotein (oxLDL) and damage to the structure or function of the endothelium …
density lipoprotein (oxLDL) and damage to the structure or function of the endothelium …
Disubstituted diaryl diselenides as potential atheroprotective compounds: Involvement of TrxR and GPx-like systems
MR Straliotto, J de Oliveira, G Mancini… - European Journal of …, 2013 - Elsevier
Oxidative modifications of low-density lipoproteins (LDLs) have a determinant role in
atherogenesis and the study of agents that can modulate LDL oxidation is of …
atherogenesis and the study of agents that can modulate LDL oxidation is of …
Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells
SK Roy Chowdhury, GV Sangle, X Xie… - American Journal …, 2010 - journals.physiology.org
Atherosclerotic cardiovascular disease is the leading cause of mortality in the Western
world. Dysfunction of the mitochondrial respiratory chain and overproduction of reactive …
world. Dysfunction of the mitochondrial respiratory chain and overproduction of reactive …
Diphenyl diselenide differently modulates cardiovascular redox responses in young adult and middle-aged low-density lipoprotein receptor knockout …
Objectives The present work aimed to investigate the effect of (PhSe) 2 on cardiovascular
age-related oxidative stress in hypercholesterolemic mice. Methods To this end, LDL …
age-related oxidative stress in hypercholesterolemic mice. Methods To this end, LDL …
Oxidation-induced loss of the ability of HDL to counteract the inhibitory effect of oxidized LDL on vasorelaxation
L Perségol, MC Brindisi, D Rageot, JP Pais de Barros… - Heart and vessels, 2015 - Springer
Several current diseases are associated with an increase in the oxidation of HDL, which is
likely to impair their functionality. Our aim was to identify whether oxidation could change the …
likely to impair their functionality. Our aim was to identify whether oxidation could change the …
[HTML][HTML] Selenium supplementation acting through the induction of thioredoxin reductase and glutathione peroxidase protects the human endothelial cell line EAhy926 …
MH Lewin, JR Arthur, RA Riemersma, F Nicol… - … et Biophysica Acta (BBA …, 2002 - Elsevier
The human endothelial cell line EAhy926 was used to determine the importance of selenium
in preventing oxidative damage induced by tert-butyl hydroperoxide (tert-BuOOH) or …
in preventing oxidative damage induced by tert-butyl hydroperoxide (tert-BuOOH) or …
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