Although a clinical connection between pain and depression has long been recognized,
how these two conditions interact remains unclear. Here we report that both mechanical …

A connection between pain and depression has long been recognized in the clinical setting;
however, its mechanism remains unclear. This study showed that mechanical hyperalgesia …

Previous study has shown that administration of melatonin into the anterior cingulate cortex
contralateral to peripheral nerve injury prevented exacerbation of mechanical allodynia with …

Clinically, it is well known that chronic pain induces depression, anxiety, and a reduced
quality of life. There have been many reports on the relationship between pain and emotion …

Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in
addition to treating depression, antidepressants such as amitriptyline are a first-line …

Although it has been accepted that depression and pain are common comorbidities, their
interaction is not fully understood. The present study was aimed to investigate the effects of …

BACKGROUND: Patients with chronic pain frequently suffer affective disorders, particularly
anxiety and depression. Although clinical research on the relationship between pain and …

Chronic pain is associated with the development of affective disorders but the underlying
mechanisms are not fully understood. Changes in brain centres implicated in both emotional …

Clinical observations suggest that depressed patients were less sensitive to experimental
pain than healthy subjects. However, few animal studies are reported concerning the …

Although pain is frequently accompanied with depression, little is known about the risk
factors contributing to individual differences to the comorbidity of pain and depression. In this …