Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy
SN Byrareddy, J Arthos, C Cicala, F Villinger, KT Ortiz… - Science, 2016 - science.org
Antiretroviral drug therapy (ART) effectively suppresses replication of both the
immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon …
immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon …
ALT-803 transiently reduces simian immunodeficiency virus replication in the absence of antiretroviral treatment
AL Ellis-Connell, AJ Balgeman, KR Zarbock… - Journal of …, 2018 - Am Soc Microbiol
Developing biological interventions to control human immunodeficiency virus (HIV)
replication in the absence of antiretroviral therapy (ART) could contribute to the development …
replication in the absence of antiretroviral therapy (ART) could contribute to the development …
Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques
Z Hel, D Venzon, M Poudyal, WP Tsai, L Giuliani… - Nature medicine, 2000 - nature.com
Prolonged antiretroviral therapy (ART) is not likely to eradicate human immunodeficiency
virus type I (HIV-I) infection. Here we explore the effect of therapeutic immunization in the …
virus type I (HIV-I) infection. Here we explore the effect of therapeutic immunization in the …
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes
JE Schmitz, MJ Kuroda, S Santra, VG Sasseville… - Science, 1999 - science.org
Clinical evidence suggests that cellular immunity is involved in controlling human
immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune …
immunodeficiency virus–1 (HIV-1) replication. An animal model of acquired immune …
[HTML][HTML] Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
The viral reservoir represents a critical challenge for human immunodeficiency virus type 1
(HIV-1) eradication strategies,,,,. However, it remains unclear when and where the viral …
(HIV-1) eradication strategies,,,,. However, it remains unclear when and where the viral …
Antiviral antibodies are necessary for control of simian immunodeficiency virus replication
To better define the role of B cells in the control of pathogenic simian immunodeficiency
virus (SIV) replication, six rhesus monkeys were depleted of B cells by intravenous infusion …
virus (SIV) replication, six rhesus monkeys were depleted of B cells by intravenous infusion …
Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
X Jin, DE Bauer, SE Tuttleton, S Lewin… - The Journal of …, 1999 - rupress.org
To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV)
replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 …
replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 …
[HTML][HTML] Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
JB McBrien, M Mavigner, L Franchitti, SA Smith… - Nature, 2020 - nature.com
Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …
Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
JE Schmitz, MJ Kuroda, S Santra, MA Simon… - Journal of …, 2003 - Am Soc Microbiol
Cellular immune responses mediated by CD8+ lymphocytes exert efficient control of virus
replication during primary simian immunodeficiency virus (SIV) infection. However, the role …
replication during primary simian immunodeficiency virus (SIV) infection. However, the role …
CD8+ lymphocytes are required for maintaining viral suppression in SIV-infected macaques treated with short-term antiretroviral therapy
EK Cartwright, L Spicer, SA Smith, D Lee, R Fast… - Immunity, 2016 - cell.com
Infection with HIV persists despite suppressive antiretroviral therapy (ART), and treatment
interruption results in rapid viral rebound. Antibody-mediated CD8+ lymphocyte depletion in …
interruption results in rapid viral rebound. Antibody-mediated CD8+ lymphocyte depletion in …