Dual regulations of thermosensitive heparin–poloxamer hydrogel using ε-polylysine: bioadhesivity and controlled KGF release for enhancing wound healing of …
HL Xu, J Xu, BX Shen, SS Zhang, BH Jin… - … Applied Materials & …, 2017 - ACS Publications
Hydrogel was not only used as an effective support matrix to prevent intrauterine adhesion
after endometrial injury but also served as scaffold to sustain release of some therapeutics …
after endometrial injury but also served as scaffold to sustain release of some therapeutics …
Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitate the morphologic and functional recovery of the injured rat uterus
HL Xu, J Xu, SS Zhang, QY Zhu, BH Jin, DL ZhuGe… - Drug Delivery, 2017 - Taylor & Francis
Endometrial injury usually results in intrauterine adhesion (IUA), which is an important cause
of infertility and recurrent miscarriage in reproductive women. There is still lack of an …
of infertility and recurrent miscarriage in reproductive women. There is still lack of an …
Using 17β‐estradiol heparin‐poloxamer thermosensitive hydrogel to enhance the endometrial regeneration and functional recovery of intrauterine adhesions in a rat …
SS Zhang, XX Xu, WW Xiang, HH Zhang… - The FASEB …, 2020 - Wiley Online Library
Mechanical damage or infection to the endometrium can lead to the formation of adhesions
in the uterine cavity, which may result in reduced reproductive outcome and/or pregnancy …
in the uterine cavity, which may result in reduced reproductive outcome and/or pregnancy …
Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17β-estradiol on endometrial regeneration for intrauterine adhesions in a …
SS Zhang, WT Xia, J Xu, HL Xu, CT Lu… - International journal …, 2017 - Taylor & Francis
Intrauterine adhesions (IUA) frequently occur after infectious or mechanical injury to the
endometrium, which may lead to infertility and/or pregnancy complications. There are few …
endometrium, which may lead to infertility and/or pregnancy complications. There are few …
Injectable, degradable, and mechanically adaptive hydrogel induced by L-serine and allyl-functionalized chitosan with platelet-rich plasma for treating intrauterine …
H Lv, R Xu, X Xie, Q Liang, W Yuan, Y Xia, X Ao, S Tan… - Acta Biomaterialia, 2024 - Elsevier
The integration of barrier materials with pharmacological therapy is a promising strategy to
treat intrauterine adhesions (IUAs). However, most of these materials are surgically …
treat intrauterine adhesions (IUAs). However, most of these materials are surgically …
Ibuprofen-loaded heparin modified thermosensitive hydrogel for inhibiting excessive inflammation and promoting wound healing
Hydrogels have been investigated as ideal biomaterials for wound treatment owing to their
ability to form a highly moist environment which accelerates cell migration and tissue …
ability to form a highly moist environment which accelerates cell migration and tissue …
A mechanically robust and stable estradiol-loaded PHEMA-based hydrogel barrier for intrauterine adhesion treatment
X Xie, R Xu, H Ouyang, S Tan, C Guo, X Luo… - Journal of Materials …, 2022 - pubs.rsc.org
Estrogen combined with physical barrier therapy may be a prospective method to repair a
damaged endometrium and prevent postsurgical re-adhesion in the treatment of intrauterine …
damaged endometrium and prevent postsurgical re-adhesion in the treatment of intrauterine …
Aloe/poloxamer hydrogel as an injectable β-estradiol delivery scaffold with multi-therapeutic effects to promote endometrial regeneration for intrauterine adhesion …
Q Yao, YW Zheng, QH Lan, LF Wang, ZW Huang… - European Journal of …, 2020 - Elsevier
Intrauterine adhesion (IUA) is characterized by endometrial stromal replaced with fibrous
tissue during the trauma or operation induced injury. Current clinic IUA management mainly …
tissue during the trauma or operation induced injury. Current clinic IUA management mainly …
Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions
P Lang, T Liu, S Huang, Z Zhou, M Zhang… - ACS Biomaterials …, 2023 - ACS Publications
Tissue adhesions could occur following surgeries, and severe tissue adhesions can lead to
serious complications. Medical hydrogels could be applied at surgical sites as a physical …
serious complications. Medical hydrogels could be applied at surgical sites as a physical …
Antifouling and injectable granular hydrogel for the prevention of postoperative intrauterine adhesion
W Xia, Q Wang, M Liu, S Lu, H Yu, H Yin… - … Applied Materials & …, 2023 - ACS Publications
Postoperative intrauterine adhesion (IUA), caused by endometrial basal layer injury, is one
of the main causes of female infertility. The excessive deposition of fibrin as well as fibroblast …
of the main causes of female infertility. The excessive deposition of fibrin as well as fibroblast …
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