Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are
defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However …

Abnormalities in CD4+ CD25+ Foxp3+ regulatory T (T reg) cells have been implicated in
susceptibility to allergic, autoimmune, and immunoinflammatory conditions. However …

Although quantitative identification and viable enrichment of natural regulatory T cells (T-
regs) in humans are problematic, such steps would greatly facilitate the analysis of these …

FOXP3+ regulatory T (Treg) cells have crucial roles in maintaining self-tolerance and
modulating adaptive immune responses. Functional studies of Treg cells have been …

Regulatory T cells (Treg) are commonly identified by CD25 (IL‐2Rα) surface expression
and/or intracellular expression of the FOXP3 transcription factor. In addition, Treg are also …

Selective suppression of effector CD4+ T cell functions is necessary to prevent immune cell–
mediated damage to healthy tissues. This appears especially true during pregnancy or in …

Regulatory T cells (Treg) are important in maintaining tolerance to self tissues. As both
CD28 and CTLA-4 molecules are implicated in the function of Treg, we investigated the …

Abstract The IL-2/IL-2R interaction is important for development and peripheral homeostasis
of T regulatory (T reg) cells. IL-2-and IL-2R-deficient mice are not completely devoid of …

Abstract CD4+ CD25+ regulatory T cells (T reg s) have far-reaching immunotherapeutic
applications, the realization of which will require a greater understanding of the factors …

CD4+ regulatory T (Treg) cells expressing CD25 and the transcription factor forkhead box
P3 (FOXP3) are indispensable for immunological self-tolerance and homeostasis. FOXP3+ …