Cardiac Small Conductance Ca2+-Activated K+ Channel Subunits Form Heteromultimers via the Coiled-Coil Domains in the C Termini of the Channels
D Tuteja, S Rafizadeh, V Timofeyev, S Wang… - Circulation …, 2010 - Am Heart Assoc
Rationale: Ca2+-activated K+ channels are present in a wide variety of cells. We have
previously reported the presence of small conductance Ca2+-activated K+ (SK or KCa) …
previously reported the presence of small conductance Ca2+-activated K+ (SK or KCa) …
[HTML][HTML] Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes
D Tuteja, D Xu, V Timofeyev, L Lu… - American Journal …, 2005 - journals.physiology.org
Abstract Small-conductance Ca 2+-activated K+ channels (SK channels, K Ca channels)
have been reported in excitable cells, where they aid in integrating changes in intracellular …
have been reported in excitable cells, where they aid in integrating changes in intracellular …
Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes
XD Zhang, V Timofeyev, N Li, RE Myers… - Cardiovascular …, 2014 - academic.oup.com
Abstract Aims Small conductance Ca2+-activated K+ channels (KCa2 or SK channels) have
been reported in excitable cells, where they aid in integrating changes in intracellular Ca2+ …
been reported in excitable cells, where they aid in integrating changes in intracellular Ca2+ …
Molecular identification and functional roles of a Ca2+-activated K+ channel in human and mouse hearts
Y Xu, D Tuteja, Z Zhang, D Xu, Y Zhang… - Journal of Biological …, 2003 - ASBMB
The repolarization phase of cardiac action potential is prone to aberrant excitation that is
common in cardiac patients. Here, we demonstrate that this phase is markedly sensitive to …
common in cardiac patients. Here, we demonstrate that this phase is markedly sensitive to …
Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias
XD Zhang, DK Lieu, N Chiamvimonvat - Heart rhythm, 2015 - Elsevier
Small-conductance Ca 2+-activated K+(SK, K Ca 2) channels are unique in that they are
gated solely by changes in intracellular Ca 2+ and, hence, function to integrate intracellular …
gated solely by changes in intracellular Ca 2+ and, hence, function to integrate intracellular …
The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system
AS Monaghan, DCH Benton, PK Bahia… - Journal of Biological …, 2004 - ASBMB
The aim of this study was to determine whether functional heteromeric channels can be
formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 …
formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with either SK1 or SK2 …
Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria
L Skibsbye, C Poulet, JG Diness… - Cardiovascular …, 2014 - academic.oup.com
Aims Small-conductance calcium-activated potassium (SK) channels are expressed in the
heart of various species, including humans. The aim of the present study was to address …
heart of various species, including humans. The aim of the present study was to address …
Assembly and trafficking of human small conductance Ca2+-activated K+ channel SK3 are governed by different molecular domains
R Roncarati, I Decimo, G Fumagalli - Molecular and Cellular Neuroscience, 2005 - Elsevier
Intracellular trafficking is an important event in the control of type and number of ion
channels expressed on the cell surface. In this study, we have identified molecular domains …
channels expressed on the cell surface. In this study, we have identified molecular domains …
Ablation of a Ca2+‐activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation
N Li, V Timofeyev, D Tuteja, D Xu, L Lu… - The Journal of …, 2009 - Wiley Online Library
Small conductance Ca2+‐activated K+ channels (SK channels) have been reported in
excitable cells, where they aid in integrating changes in intracellular Ca2+ (Ca2+ i) with …
excitable cells, where they aid in integrating changes in intracellular Ca2+ (Ca2+ i) with …
Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes
JM Hancock, KL Weatherall, SC Choisy, AF James… - Heart Rhythm, 2015 - Elsevier
Background Activation of small conductance calcium-activated potassium (SK) channels is
proposed to contribute to repolarization of the action potential in atrial myocytes. This role is …
proposed to contribute to repolarization of the action potential in atrial myocytes. This role is …