Repair of the adult mammalian spinal cord is prohibited by several extrinsic and intrinsic
factors. As the CNS matures, growth-promoting proteins such as integrins are …

After spinal cord injury (SCI), regeneration of adult motor axons such as axons in the
corticospinal tract (CST) is severely limited. Alongside the inhibitory lesion environment …

Murine and human iPSC-NS/PCs (induced pluripotent stem cell-derived neural
stem/progenitor cells) promote functional recovery following transplantation into the injured …

After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the
highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C …

Introduction Induced pluripotent stem cells (iPSCs) have emerged as a promising cell
source for immune-compatible cell therapy. Although a variety of somatic cells have been …

Numerous interventions have been explored in animal models using cells differentiated from
human induced pluripotent stem cells (iPSCs) in the context of neural injury with some …

The goal of stem cell therapy for spinal cord injury (SCI) is to restore motor function without
exacerbating pain. Induced pluripotent stem cells (iPSC) may be administered by …

Neural progenitor cells (NPCs) have shown modest potential and some side effects (eg
allodynia) for treatment of spinal cord injury (SCI). In only a few cases, however, have NPCs …

The peripheral branch of sensory dorsal root ganglion (DRG) neurons regenerates readily
after injury unlike their central branch in the spinal cord. However, extensive regeneration …

Stem cell treatments for spinal cord injury (SCI) are effective in pre-clinical animal model
research but not yet for humans. Two promising stem cell repair strategies involve (1) …