Significance: The incidence of cardiovascular events (CVEs) increases with age,
representing the main cause of death in an elderly population. Aging is associated with …

Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

Vascular ageing can be envisioned as the consequence of the accumulation of reactive
oxygen species (ROS) associated with generalized endothelial dysfunction. Oxidative stress …

Atherosclerosis is a multifactorial disease for which the molecular etiology of many of the risk
factors is still unknown. As no single genetic marker or test accurately predicts …

Although epidemiologic studies have revealed that high plasma cholesterol or high
homocysteine levels, as well as diabetes, hypertension and smoking are important risk …

Numerous reports on the molecular mechanism of atherogenesis indicate an increase in
oxidative stress, formation of advanced glycoxidation end products (AGEs), chronic …

Characteristic morphological and molecular alterations such as vessel wall thickening and
reduction of nitric oxide occur in the aging vasculature leading to the gradual loss of …

Oxidative stress and inflammation are increased with advancing age. Evidence suggests
that oxidative stress and inflammation both lead to impaired vascular function. There is also …

The initiating event of atherogenesis is thought to be an injury to the vessel wall resulting in
endothelial dysfunction. This is followed by key features of atherosclerotic plaque formation …

Atherothrombosis remains one of the main causes of morbidity and mortality worldwide. The
underlying pathology is a chronic pathological vascular remodeling of the arterial wall …