Arh1p is an essential mitochondrial protein of yeast with reductase activity. Here we show
that this protein is involved in iron metabolism. A yeast strain was constructed in which the …

Iron regulatory proteins (IRP) are sequence-specific RNA-binding proteins that mediate iron-
responsive gene regulation in animals. IRP1 is also the cytosolic isoform of aconitase (c …

Mitochondria transport and utilize iron for the synthesis of haem and Fe–S clusters. Although
many proteins are known to be involved in these processes, additional proteins are likely to …

Iron is fundamental to many biological processes, but is also detrimental as it fosters the
synthesis of destructive oxygen radicals. Recent experiments have increased our …

Saccharomyces cerevisiae responds to iron deprivation by increasing the transcription of
genes involved in the uptake of environmental iron and in the mobilization of vacuolar iron …

Mitochondria are responsible for the synthesis of both iron-sulfur clusters and heme, but the
potential connection between the two major iron-consuming pathways is unknown. Here, we …

The mammalian electron transfer chain of mitochondrial cytochrome P450 forms involved in
steroidogenesis includes very specific proteins, namely adrenodoxin reductase and …

The yeast genes MRS3 and MRS4 encode two members of the mitochondrial carrier family
with high sequence similarity. To elucidate their function we utilized genome-wide …

High affinity iron uptake in Saccharomyces cerevisiae requires a metal reductase, a
multicopper ferroxidase, and an iron permease. Fet3, the apparent ferroxidase, is proposed …

Yah1p, an [Fe2S2]-containing ferredoxin located in the matrix of Saccharomyces cerevisiae
mitochondria, functions in the synthesis of Fe/S clusters and heme a prosthetic groups. EPR …