Genetic variation in the regulation, expression and activity of genes coding for Phase I,
Phase II drug metabolizing enzymes (DMEs) and drug targets, can be defining factors for the …

Gene polymorphism and single nucleotide polymorphism (SNPs) called" snips" might play a
pivotal role in the future of the clinical therapy. Although not much is known about the …

Pharmacogenetics (or pharmacogenomics) studies the role of inherited and acquired
genetic variation in drug response. Clinically relevant pharmacogenetic examples, mainly …

The basic principle of drug and xenobiotic metabolism in the body is to make them more
water soluble and thus more readily excreted in the urine. Genetic polymorphisms of phases …

Differences in response to medications both in terms of clinical activity and side-effects have
long been recognised by physicians. Genetics has been recently considered as a potential …

Inter-individual differences in genes for drug metabolising enzymes and drug transporters
are important for understanding efficacy in drug therapy. These differences are important …

Aims: To study the frequency distribution of cytochrome P450 (CYP) functional genetic
variants in five Eurasian populations from the territory of Siberia in Russia. Materials & …

Important interindividual differences in drug pharmacokinetics cause absence of drug
response or adverse drug reactions in significant fractions of the populations. The …

Data on frequency of pharmacogenetic polymorphisms in the UK population are limited.
However, availability of whole genome sequencing data on 94 UK controls of European …

The extent of genetic variation found in drug metabolism genes and its contribution to
interindividual variation in response to medication remains incompletely understood. To …