[PDF][PDF] Distribution of the most common genetic variants associated with a variable drug response in the population of the Republic of Macedonia
KA Nestorovska, K Jakovski, Z Naumovska… - Balkan Journal of …, 2014 - sciendo.com
Genetic variation in the regulation, expression and activity of genes coding for Phase I,
Phase II drug metabolizing enzymes (DMEs) and drug targets, can be defining factors for the …
Phase II drug metabolizing enzymes (DMEs) and drug targets, can be defining factors for the …
[PDF][PDF] Individualized drug response related to genetic variations of cytochrome P450 isoforms and other enzymes
MS Paveliu, S Bengea, FS Paveliu - Rev Farmacia, 2010 - Citeseer
Gene polymorphism and single nucleotide polymorphism (SNPs) called" snips" might play a
pivotal role in the future of the clinical therapy. Although not much is known about the …
pivotal role in the future of the clinical therapy. Although not much is known about the …
Genetic and epigenetic factors affecting cytochrome P450 phenotype and their clinical relevance
V Tamási, A Falus - Topics on Drug Metabolism, 2012 - books.google.com
Pharmacogenetics (or pharmacogenomics) studies the role of inherited and acquired
genetic variation in drug response. Clinically relevant pharmacogenetic examples, mainly …
genetic variation in drug response. Clinically relevant pharmacogenetic examples, mainly …
Genotyping of the polymorphic drug metabolizing enzymes cytochrome P450 2D6 and 1A1, and N-acetyltransferase 2 in a Russian sample
EA Gaikovitch - 2003 - edoc.hu-berlin.de
The basic principle of drug and xenobiotic metabolism in the body is to make them more
water soluble and thus more readily excreted in the urine. Genetic polymorphisms of phases …
water soluble and thus more readily excreted in the urine. Genetic polymorphisms of phases …
Genetics/genomics and drug effects
F Heller - Acta Clinica Belgica, 2013 - Taylor & Francis
Differences in response to medications both in terms of clinical activity and side-effects have
long been recognised by physicians. Genetics has been recently considered as a potential …
long been recognised by physicians. Genetics has been recently considered as a potential …
Drug metabolising enzyme polymorphisms in Middle-and Eastern-European Slavic populations
JA Hubacek - Drug metabolism and drug interactions, 2014 - degruyter.com
Inter-individual differences in genes for drug metabolising enzymes and drug transporters
are important for understanding efficacy in drug therapy. These differences are important …
are important for understanding efficacy in drug therapy. These differences are important …
Global pharmacogenetics: genetic substructure of Eurasian populations and its effect on variants of drug-metabolizing enzymes
O Makeeva, V Stepanov, V Puzyrev… - …, 2008 - Taylor & Francis
Aims: To study the frequency distribution of cytochrome P450 (CYP) functional genetic
variants in five Eurasian populations from the territory of Siberia in Russia. Materials & …
variants in five Eurasian populations from the territory of Siberia in Russia. Materials & …
Pharmacogenetic biomarkers as tools for improved drug therapy; emphasis on the cytochrome P450 system
M Ingelman-Sundberg, SC Sim - Biochemical and biophysical research …, 2010 - Elsevier
Important interindividual differences in drug pharmacokinetics cause absence of drug
response or adverse drug reactions in significant fractions of the populations. The …
response or adverse drug reactions in significant fractions of the populations. The …
Pharmacogenetics of drug metabolizing enzymes in the United Kingdom population: review of current knowledge and comparison with selected European …
AK Daly - Drug metabolism and personalized therapy, 2015 - degruyter.com
Data on frequency of pharmacogenetic polymorphisms in the UK population are limited.
However, availability of whole genome sequencing data on 94 UK controls of European …
However, availability of whole genome sequencing data on 94 UK controls of European …
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population
JF Solus, BJ Arietta, JR Harris, DP Sexton… - …, 2004 - Taylor & Francis
The extent of genetic variation found in drug metabolism genes and its contribution to
interindividual variation in response to medication remains incompletely understood. To …
interindividual variation in response to medication remains incompletely understood. To …