The enantiomer of endomorphin-1 (Tyr-Pro-Trp-PheNH2) and the analogues containing (S)-
or (R)-β-proline have been synthesized, and their affinities towards μ-opioid receptors have …

In this paper we describe the synthesis and affinity toward the μ-opioid receptor of some
tetrapeptides obtained from endomorphin-1, H-Tyr-Pro-Trp-Phe-NH2 (1), by substituting …

Endomorphin-1 (Tyr-Pro-Trp-PheNH2) has been proposed as the most potent endogenous
ligand of the μ-opioid receptors. In this paper, we describe the synthesis of some …

A series of diastereoisomers of endomorphin-1 (EM1, Tyr 1-Pro 2-Trp 3-Phe 4-NH 2) have
been synthesized and their potency measured using the guinea pig ileum assay.[d-Phe 4] …

Endogenous μ-opioid receptor (MOR) selective peptides, endomorphin-1 (EM-1) and
endomorphin-2 (EM-2), unlike so called 'typical opioids', are characterized by the presence …

Endomorphin (EM2, Tyr–Pro–Phe–Phe–NH2) can assume various conformations related to
cis/trans-rotamers of the amide linkage of Tyr–Pro. To control isomerization, restricted or …

The opioid agonists endomorphins (Tyr–Pro–Trp–Phe–NH2; EM1 and Tyr–Pro–Phe–Phe–
NH2; EM2) and morphiceptin (Tyr–Pro–Phe–Pro–NH2) exhibit an extremely high selectivity …

Recently, we reported synthesis and activity of a constrained cyclic analogue of
endomorphin-2 (EM-2: Tyr-Pro-Phe-Phe-NH2) and related linear models containing the cis …

All sixteen stereoisomeric analogues of endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2) were
synthesized by Fmoc-strategy using solid phase methods. Although synthetic endomorphin …

The newly discovered endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-
Phe-Phe-NH2) are potent opioid peptides with the highest affinity and selectivity for the μ …