Biophysical cues encoded in the extracellular matrix (ECM) are increasingly being explored
to control cell behavior in tissue engineering applications. Recently, we showed that cell …

Engineering of cellular assembly on biomaterial scaffolds by utilizing microscale
topographical cues has emerged as a powerful strategy in cardiovascular tissue …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Most tissue cells evolve in vivo in a three-dimensional (3D) microenvironment including
complex topographical patterns. Cells exert contractile forces to adhere and migrate through …

The extracellular matrix is composed of a variety of proteins, polysaccharides, and
glycosaminoglycans that self-assemble into a hierarchical order of nanometer-to micrometer …

In this report, we describe using ultraviolet (UV)-assisted capillary force lithography (CFL) to
create a model substratum of anisotropic micro-and nanotopographic pattern arrays with …

Cell interactions with the extracellular matrix (ECM) are critical to cell and tissue functions
involving adhesion, communication, and differentiation. Three-dimensional (3D) in vitro …

Mammalian cells redirect their movement in response to changes in the physical properties
of their extracellular matrix (ECM) adhesive scaffolds, including changes in available …

Cryogenic electron tomography is the highest resolution tool available for structural analysis
of macromolecular organization inside cells. Micropatterning of extracellular matrix (ECM) …

Physical forces generated by cells drive morphologic changes during development and can
feedback to regulate cellular phenotypes. Because these phenomena typically occur within …