[HTML][HTML] Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial

EJ Lenze, C Mattar, CF Zorumski, A Stevens… - Jama, 2020 - jamanetwork.com
Importance Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of
an excessive immune response. Fluvoxamine may prevent clinical deterioration by …

Higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19: the ACTIV-6 randomized clinical trial

TG Stewart, PA Rebolledo, A Mourad, CJ Lindsell… - JAMA, 2023 - jamanetwork.com
Importance The effect of higher-dose fluvoxamine in reducing symptom duration among
outpatients with mild to moderate COVID-19 remains uncertain. Objective To assess the …

Effect of fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19: a randomized clinical trial

MW McCarthy, S Naggie, DR Boulware, CJ Lindsell… - JAMA, 2023 - jamanetwork.com
Importance The effectiveness of fluvoxamine to shorten symptom duration or prevent
hospitalization among outpatients with mild to moderate symptomatic COVID-19 is unclear …

Fluvoxamine for the early treatment of SARS-CoV-2 infection: a review of current evidence

SN Facente, AM Reiersen, EJ Lenze, DR Boulware… - Drugs, 2021 - Springer
SARS-CoV-2 infection causes COVID-19, which frequently leads to clinical deterioration
and/or long-lasting morbidity. Academic and governmental experts throughout the USA met …

[HTML][HTML] Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform …

G Reis, EA dos Santos Moreira-Silva… - The Lancet Global …, 2022 - thelancet.com
Background Recent evidence indicates a potential therapeutic role of fluvoxamine for
COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we …

Fluvoxamine for outpatient management of COVID-19 to prevent hospitalization: a systematic review and meta-analysis

TC Lee, S Vigod, É Bortolussi-Courval… - JAMA network …, 2022 - jamanetwork.com
Importance Widely available and affordable options for the outpatient management of
COVID-19 are needed, particularly for therapies that prevent hospitalization. Objective To …

Safety and efficacy of fluvoxamine in COVID‐19 ICU patients: an open label, prospective cohort trial with matched controls

M Calusic, R Marcec, L Luksa, I Jurkovic… - British journal of …, 2022 - Wiley Online Library
Aims Fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) and sigma‐1 receptor
agonist, has so far shown promise in the prevention of COVID‐19 progression as an early …

Oral fluvoxamine with inhaled budesonide for treatment of early-onset COVID-19: a randomized platform trial

G Reis, EA dos Santos Moreira Silva… - Annals of internal …, 2023 - acpjournals.org
Background: Previous trials have demonstrated the effects of fluvoxamine alone and inhaled
budesonide alone for prevention of disease progression among outpatients with COVID-19 …

Prospective cohort of fluvoxamine for early treatment of coronavirus disease 19

D Seftel, DR Boulware - Open Forum Infectious Diseases, 2021 - academic.oup.com
We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-
19) in a prospective cohort in the setting of a mass outbreak. Overall, 65 persons opted to …

[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19

VP Sukhatme, AM Reiersen, SJ Vayttaden… - Frontiers in …, 2021 - frontiersin.org
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …