Design, simulation, and evaluation of polymer-based microfluidic devices via computational fluid dynamics and cell culture “on-chip”

N Bakuova, S Toktarkan, D Dyussembinov, D Azhibek… - Biosensors, 2023 - mdpi.com
Organ-on-a-chip (OoC) technology has experienced exponential growth driven by the need
for a better understanding of in-organ processes and the development of novel approaches …

Development of a hybrid polymer-based microfluidic platform for culturing hepatocytes towards liver-on-a-chip applications

G Kulsharova, A Kurmangaliyeva, E Darbayeva… - Polymers, 2021 - mdpi.com
The drug development process can greatly benefit from liver-on-a-chip platforms aiming to
recapitulate the physiology, mechanisms, and functionalities of liver cells in an in vitro …

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

N Farhang Doost, SK Srivastava - Biosensors, 2024 - mdpi.com
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a
microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures …

Microfluidic organ-on-a-chip system for disease modeling and drug development

Z Li, J Hui, P Yang, H Mao - Biosensors, 2022 - mdpi.com
An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …

[HTML][HTML] Toward a modular, integrated, miniaturized, and portable microfluidic flow control architecture for organs-on-chips applications

G Özkayar, JC Lötters, M Tichem, MK Ghatkesar - Biomicrofluidics, 2022 - pubs.aip.org
Microfluidic organs-on-chips (OoCs) technology has emerged as the trend for in vitro
functional modeling of organs in recent years. Simplifying the complexities of the human …

Organs-on-chips and its applications

SUN Wei, C Yu-Qing, LUO Guo-An, M Zhang… - Chinese Journal of …, 2016 - Elsevier
Microfluidic chips have been proven to be attractive platforms for cell culture in vitro.
Microfluidic chip-based organs-on-chips technology has received more attention because it …

[HTML][HTML] Numerical evaluation and experimental validation of fluid flow behavior within an organ-on-a-chip model

V Carvalho, IM Gonçalves, N Rodrigues… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective By combining biomaterials, cell culture, and microfluidic
technology, organ-on-a-chip (OoC) platforms have the ability to reproduce the physiological …

Leaf-templated, microwell-integrated microfluidic chips for high-throughput cell experiments

M Mao, J He, Y Lu, X Li, T Li, W Zhou, D Li - Biofabrication, 2018 - iopscience.iop.org
As an alternative to conventional cell culture and animal testing, an organ-on-a-chip is
applied to study the biological phenomena of organ development and disease, as well as …

Organ-on-a-chip platforms for drug screening and tissue engineering

Z Wang, R Samanipour, K Kim - Biomedical engineering: frontier research …, 2016 - Springer
Developments in micro-and nanofluidic technologies have led to new kinds of cell culture
and screening systems that are collectively termed organ-on-a-chip systems. Organ-on-a …

Microfluidic organ‐on‐a‐chip technology for advancement of drug development and toxicology

JD Caplin, NG Granados, MR James… - Advanced …, 2015 - Wiley Online Library
In recent years, the exploitation of phenomena surrounding microfluidics has seen an
increase in popularity, as researchers have found a way to use their unique properties to …