Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in
8000 births. Although the proportion of familial CPHD cases is unknown, about 10% have an …

Objective Homozygous mutations in the gene encoding the pituitary transcription factor
PROP1 are associated with combined pituitary hormone deficiency (CPHD) in both mice …

As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in
the development and organogenesis of this gland may account for a form of combined …

Alterations of the gene encoding the pituitary transcription factor PROP1 were associated
with congenital forms of multiple pituitary hormone deficiencies in several families. Among …

As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in
the development and organogenesis of this gland may account for a form of combined …

Incomplete differentiation of the anterior pituitary (AP) hormone-secreting cells can result in
combined pituitary hormone deficiency (CPHD), in which patients display deficiencies in GH …

Objective Mutations of the PROP1 gene lead to combined pituitary hormone deficiency
(CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less …

Objective Mutations within the pituitary‐specific paired‐like homeobox gene PROP1 have
been described in 50–100% of patients with familial combined pituitary hormone deficiency …

Mutations in the prophet of Pit-1 gene (PROP1) have been shown to be responsible for
combined pituitary hormone deficiency (CPHD) with deficiencies of growth hormone (GH) …

Genomic DNA from 18 patients with combined pituitary hormone deficiency was screened
for 2-bp deletion (A301, G302) in PROP1 gene by Bcg I restriction endonuclease analysis of …