Structures of bacterial homologues of SWEET transporters in two distinct conformations

Y Xu, Y Tao, LS Cheung, C Fan, LQ Chen, S Xu… - Nature, 2014 - nature.com
SWEETs and their prokaryotic homologues are monosaccharide and disaccharide
transporters that are present from Archaea to plants and humans,,. SWEETs play crucial …

Structure of a eukaryotic SWEET transporter in a homotrimeric complex

Y Tao, LS Cheung, S Li, JS Eom, LQ Chen, Y Xu… - Nature, 2015 - nature.com
Eukaryotes rely on efficient distribution of energy and carbon skeletons between organs in
the form of sugars. Glucose in animals and sucrose in plants serve as the dominant …

Crystal structure of a bacterial homologue of SWEET transporters

J Wang, C Yan, Y Li, K Hirata, M Yamamoto, N Yan… - Cell Research, 2014 - nature.com
SWEETs represent a novel family of membrane sugar transporters that have been identified
in plants, worms, and mammals. They selectively transport mono-or disaccharides across …

Functional role of oligomerization for bacterial and plant SWEET sugar transporter family

YH Xuan, YB Hu, LQ Chen, D Sosso… - Proceedings of the …, 2013 - National Acad Sciences
Eukaryotic sugar transporters of the MFS and SWEET superfamilies consist of 12 and 7 α-
helical transmembrane domains (TMs), respectively. Structural analyses indicate that MFS …

Structure and function of SemiSWEET and SWEET sugar transporters

L Feng, WB Frommer - Trends in biochemical sciences, 2015 - cell.com
SemiSWEETs and SWEETs have emerged as unique sugar transporters. First discovered in
plants with the help of fluorescent biosensors, homologs exist in all kingdoms of life …

Sugar transporters for intercellular exchange and nutrition of pathogens

LQ Chen, BH Hou, S Lalonde, H Takanaga… - Nature, 2010 - nature.com
Sugar efflux transporters are essential for the maintenance of animal blood glucose levels,
plant nectar production, and plant seed and pollen development. Despite broad biological …

Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter

Y Lee, T Nishizawa, K Yamashita, R Ishitani… - Nature …, 2015 - nature.com
SWEET family proteins mediate sugar transport across biological membranes and play
crucial roles in plants and animals. The SWEETs and their bacterial homologues, the …

Phylogenetic evidence for a fusion of archaeal and bacterial SemiSWEETs to form eukaryotic SWEETs and identification of SWEET hexose transporters in the …

YB Hu, D Sosso, XQ Qu, LQ Chen, L Ma… - The FASEB …, 2016 - Wiley Online Library
SWEETs represent a new class of sugar transporters first described in plants, animals, and
humans and later in prokaryotes. Plant SWEETs play key roles in phloem loading, seed …

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

L Sun, X Zeng, C Yan, X Sun, X Gong, Y Rao, N Yan - Nature, 2012 - nature.com
Glucose transporters are essential for metabolism of glucose in cells of diverse organisms
from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 …

Structure and regulation of SWEET transporters in plants: An update

A Anjali, U Fatima, MS Manu, S Ramasamy… - Plant Physiology and …, 2020 - Elsevier
Sugar will eventually be exported transporters (SWEETs), a novel family of sugar
transporters found in both eukaryotes and prokaryotes, facilitate sugar flux across the cell …