Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
V Quesada, L Conde, N Villamor, GR Ordóñez… - Nature …, 2012 - nature.com
Here we perform whole-exome sequencing of samples from 105 individuals with chronic
lymphocytic leukemia (CLL),, the most frequent leukemia in adults in Western countries. We …
lymphocytic leukemia (CLL),, the most frequent leukemia in adults in Western countries. We …
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
L Wang, MS Lawrence, Y Wan… - … England Journal of …, 2011 - Mass Medical Soc
Background The somatic genetic basis of chronic lymphocytic leukemia, a common and
clinically heterogeneous leukemia occurring in adults, remains poorly understood. Methods …
clinically heterogeneous leukemia occurring in adults, remains poorly understood. Methods …
SF3B1 mutations in chronic lymphocytic leukemia
Y Wan, CJ Wu - Blood, The Journal of the American Society of …, 2013 - ashpublications.org
SF3B1 is a critical component of the splicing machinery, which catalyzes the removal of
introns from precursor messenger RNA (mRNA). Next-generation sequencing studies have …
introns from precursor messenger RNA (mRNA). Next-generation sequencing studies have …
[HTML][HTML] Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia
Mutations in SF3B1, which encodes a spliceosome component, are associated with poor
outcome in chronic lymphocytic leukemia (CLL), but how these contribute to CLL …
outcome in chronic lymphocytic leukemia (CLL), but how these contribute to CLL …
Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness
The genetic lesions identified in chronic lymphocytic leukemia (CLL) do not entirely
recapitulate the disease pathogenesis and the development of serious complications, such …
recapitulate the disease pathogenesis and the development of serious complications, such …
[HTML][HTML] Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
AD Tang, CM Soulette, MJ van Baren, K Hart… - Nature …, 2020 - nature.com
While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-
length isoform changes may better elucidate the functional consequences of these …
length isoform changes may better elucidate the functional consequences of these …
The impact of SF3B1 mutations in CLL on the DNA-damage response
GD te Raa, IAM Derks, V Navrkalová, A Skowronska… - Leukemia, 2015 - nature.com
Mutations or deletions in TP53 or ATM are well-known determinants of poor prognosis in
chronic lymphocytic leukemia (CLL), but only account for approximately 40% of chemo …
chronic lymphocytic leukemia (CLL), but only account for approximately 40% of chemo …
[HTML][HTML] Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics
DA Landau, CJ Wu - Genome medicine, 2013 - Springer
Chronic lymphocytic leukemia (CLL) has been consistently at the forefront of genetic
research owing to its prevalence and the accessibility of sample material. Recently, genome …
research owing to its prevalence and the accessibility of sample material. Recently, genome …
[HTML][HTML] A murine model of chronic lymphocytic leukemia based on B cell-restricted expression of Sf3b1 mutation and Atm deletion
SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the
pathogenesis of CLL remains elusive. Here, we show that conditional expression of Sf3b1 …
pathogenesis of CLL remains elusive. Here, we show that conditional expression of Sf3b1 …
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
V Ljungström, D Cortese, E Young… - Blood, The Journal …, 2016 - ashpublications.org
Fludarabine, cyclophosphamide, and rituximab (FCR) is first-line treatment of medically fit
chronic lymphocytic leukemia (CLL) patients; however, despite good response rates, many …
chronic lymphocytic leukemia (CLL) patients; however, despite good response rates, many …
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