Here we perform whole-exome sequencing of samples from 105 individuals with chronic
lymphocytic leukemia (CLL),, the most frequent leukemia in adults in Western countries. We …

Background The somatic genetic basis of chronic lymphocytic leukemia, a common and
clinically heterogeneous leukemia occurring in adults, remains poorly understood. Methods …

SF3B1 is a critical component of the splicing machinery, which catalyzes the removal of
introns from precursor messenger RNA (mRNA). Next-generation sequencing studies have …

Mutations in SF3B1, which encodes a spliceosome component, are associated with poor
outcome in chronic lymphocytic leukemia (CLL), but how these contribute to CLL …

The genetic lesions identified in chronic lymphocytic leukemia (CLL) do not entirely
recapitulate the disease pathogenesis and the development of serious complications, such …

While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-
length isoform changes may better elucidate the functional consequences of these …

Mutations or deletions in TP53 or ATM are well-known determinants of poor prognosis in
chronic lymphocytic leukemia (CLL), but only account for approximately 40% of chemo …

Chronic lymphocytic leukemia (CLL) has been consistently at the forefront of genetic
research owing to its prevalence and the accessibility of sample material. Recently, genome …

SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the
pathogenesis of CLL remains elusive. Here, we show that conditional expression of Sf3b1 …

Fludarabine, cyclophosphamide, and rituximab (FCR) is first-line treatment of medically fit
chronic lymphocytic leukemia (CLL) patients; however, despite good response rates, many …