Biofilms in chronic infections–a matter of opportunity–monospecies biofilms in multispecies infections

M Burmølle, TR Thomsen, M Fazli, I Dige… - FEMS Immunology & …, 2010 - academic.oup.com
It has become evident that aggregation or biofilm formation is an important survival
mechanism for bacteria in almost any environment. In this review, we summarize recent …

Do Mixed-Species Biofilms Dominate in Chronic Infections?–Need for in situ Visualization of Bacterial Organization

L Kvich, M Burmølle, T Bjarnsholt… - Frontiers in cellular and …, 2020 - frontiersin.org
Chronic infections present a serious economic burden to health-care systems. The severity
and prevalence of chronic infections are continuously increasing due to an aging population …

The role of bacterial biofilms in chronic infections

T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

The non-attached biofilm aggregate

KN Kragh, T Tolker-Nielsen, M Lichtenberg - Communications Biology, 2023 - nature.com
Biofilms have conventionally been perceived as dense bacterial masses on surfaces,
following the five-step model of development. Initial biofilm research focused on surface …

Studying bacterial multispecies biofilms: where to start?

HL Røder, SJ Sørensen, M Burmølle - Trends in microbiology, 2016 - cell.com
The high prevalence and significance of multispecies biofilms have now been demonstrated
in various bacterial habitats with medical, industrial, and ecological relevance. It is highly …

Current understanding of multi‐species biofilms

L Yang, Y Liu, H Wu, N Høiby, S Molin… - International journal of …, 2011 - nature.com
Direct observation of a wide range of natural microorganisms has revealed the fact that the
majority of microbes persist as surface‐attached communities surrounded by matrix …

The in vivo biofilm

T Bjarnsholt, M Alhede, M Alhede… - Trends in …, 2013 - cell.com
Bacteria can grow and proliferate either as single, independent cells or organized in
aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm …

Options and limitations in clinical investigation of bacterial biofilms

M Magana, C Sereti, A Ioannidis… - Clinical Microbiology …, 2018 - Am Soc Microbiol
Bacteria can form single-and multispecies biofilms exhibiting diverse features based upon
the microbial composition of their community and microenvironment. The study of bacterial …

Biofilm formation and dispersal and the transmission of human pathogens

L Hall-Stoodley, P Stoodley - Trends in microbiology, 2005 - cell.com
Several pathogenic bacterial species that are found in the environment can form complex
multicellular structures on surfaces known as biofilms. Pseudomonas aeruginosa, Vibrio …

Evolving concepts in biofilm infections

L Hall‐Stoodley, P Stoodley - Cellular microbiology, 2009 - Wiley Online Library
Several pathogens associated with chronic infections, including Pseudomonas aeruginosa
in cystic fibrosis pneumonia, Haemophilus influenzae and Streptococcus pneumoniae in …