Intricate processes in the thymus and periphery help curb the development and activation of
autoreactive T cells. The subtle signals that govern these processes are an area of great …

To investigate how CD4+ T cells function against a bacterial pathogen, we generated a
Listeria monocytogenes-specific CD4+ T cell model. In this system, two TCRtg mouse lines …

Helper T cells are critical for protective immunity, CD8+ T-cell memory, and CD4+ recall
responses, but whether the same or distinct CD4+ T cells are involved in these responses …

CD8 T cells play a critical role in the control and eradication of intracellular pathogens.
Increased understanding of CD8 T cell biology provides insight that can be translated into …

Linker for activation of T cells (LAT) is a transmembrane adaptor protein that links TCR
engagement to downstream signaling events. Although it is clear that LAT is essential in …

We used an ovalbumin (OVA)-specific αβ-TCR transgenic mouse system to examine the
cellular basis of CD4+ T helper (Th) phenotype development in vitro. Heat-killed Listerla …

In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T
cells following Listeria infection. Our results show that CD4 T cells responding to infection …

Adaptation of the T cell activation threshold may be one mechanism to control autoreactivity.
To investigate its occurrence in vivo, we engineered a transgenic mouse model with …

Naïve CD4+ T cells experience weak T cell receptor (TCR) signals induced by self-peptides
presented by MHC II. To investigate how these “basal” TCR signals influence responses to …

The quality of T cell responses depends on the lymphocytes' ability to undergo clonal
expansion, acquire effector functions, and traffic to the site of infection. Although TCR signal …