Glioblastoma multiforme, a highly aggressive tumor of the central nervous system, has a
dismal prognosis that is due in part to its resistance to radio-and chemotherapy. The protein …

Abstract Protein kinase D1 (PKD1) is a serine/threonine kinase that belongs to the
calcium/calmodulin-dependent kinase family, and is involved in multiple mechanisms …

Abstract Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD
family of calcium–calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and …

Protein kinase D is a family of evolutionarily conserved serine/threonine kinases that
belongs to the Ca++/Calmodulin-dependent kinase superfamily. Signal transduction …

Protein kinase D1, PKD1, is a novel serine/threonine kinase whose altered expression and
dysregulation in many tumors as well as its activation by several mitogens suggest that this …

Abstract Protein kinase D1 (PKD1) is a serine-threonine kinase that regulates various
functions within the cell, including cell proliferation, apoptosis, adhesion, and cell motility. In …

Neurotensin (NT) stimulates protein kinase D1 (PKD1), extracellular signal regulated kinase
(ERK), c‐Jun N‐terminal Kinase (JNK), and DNA synthesis in the human pancreatic …

Abstract Protein kinase D2 (PKD2) has been demonstrated to promote tumorigenesis in
many types of cancers. However, how PKD2 regulates cancer cell growth is largely …

Glioblastoma multiforme (GBM) is the most common malignant brain tumor, which, despite
combined modality treatment, reoccurs and is invariably fatal for affected patients. Recently …

Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked
by non-isoform specific protein kinase C (PKC) inhibitors, eg calphostin C, staurosporine …