Contribution and Interaction of Shiga Toxin Genes to Escherichia coli O157:H7 Virulence

GAM Tarr, T Stokowski, S Shringi, PI Tarr… - Toxins, 2019 - mdpi.com
Escherichia coli O157: H7 is the predominant cause of diarrhea-associated hemolytic
uremic syndrome (HUS) worldwide. Its cardinal virulence traits are Shiga toxins, which are …

[HTML][HTML] Association between Shiga toxin–producing Escherichia coli O157: H7 stx gene subtype and disease severity, England, 2009–2019

L Byrne, N Adams, C Jenkins - Emerging infectious diseases, 2020 - ncbi.nlm.nih.gov
Signs and symptoms of Shiga toxin–producing Escherichia coli (STEC) serogroup O157: H7
infection range from mild gastrointestinal to bloody diarrhea and hemolytic uremic syndrome …

Insight into Shiga toxin genes encoded by Escherichia coli O157 from whole genome sequencing

PM Ashton, N Perry, R Ellis, L Petrovska, J Wain… - PeerJ, 2015 - peerj.com
The ability of Shiga toxin-producing Escherichia coli (STEC) to cause severe illness in
humans is determined by multiple host factors and bacterial characteristics, including Shiga …

Shiga toxin 2 overexpression in Escherichia coli O157: H7 strains associated with severe human disease

M Neupane, GS Abu-Ali, A Mitra, DW Lacher… - Microbial …, 2011 - Elsevier
Variation in disease severity among Escherichia coli O157: H7 infections may result from
differential expression of Shiga toxin 2 (Stx2). Eleven strains belonging to four prominent …

[HTML][HTML] Mucus-activatable Shiga toxin genotype stx2d in Escherichia coli O157: H7

S Sánchez, MT Llorente, L Herrera-León… - Emerging infectious …, 2017 - ncbi.nlm.nih.gov
We identified the mucus-activatable Shiga toxin genotype stx2d in the most common
hemolytic uremic syndrome–associated Escherichia coli serotype, O157: H7. stx2d was …

Epidemiology of Shiga Toxin-Producing Escherichia coli O157 in the Province of Alberta, Canada, 2009–2016

LF Lisboa, J Szelewicki, A Lin, S Latonas, V Li, S Zhi… - Toxins, 2019 - mdpi.com
Shiga toxin-producing Escherichia coli (STEC) infections are the product of the interaction
between bacteria, phages, animals, humans, and the environment. In the late 1980s, Alberta …

Escherichia coli Harboring Shiga Toxin 2 Gene Variants: Frequency and Association with Clinical Symptoms

AW Friedrich, M Bielaszewska… - The Journal of …, 2002 - academic.oup.com
Abstract Shiga toxin (Stx)–producing Escherichia coli (STEC) from patients with hemolytic-
uremic syndrome (HUS), patients with diarrhea without HUS, or asymptomatic subjects were …

Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection

ME Wickham, C Lupp, M Mascarenhas… - The Journal of …, 2006 - academic.oup.com
Abstract Although O157: H7 Shiga toxin–producing Escherichia coli (STEC) are the
predominant cause of hemolytic-uremic syndrome (HUS) in the world, non-O157: H7 …

Lineage and Host Source Are Both Correlated with Levels of Shiga Toxin 2 Production by Escherichia coli O157:H7 Strains

Y Zhang, C Laing, Z Zhang, J Hallewell… - Applied and …, 2010 - Am Soc Microbiol
Escherichia coli O157: H7 strains fall into three major genetic lineages that differ in their
distribution among humans and cattle. Several recent studies have reported differences in …

Comparison of Shiga-like toxin II expression between two genetically diverse lineages of Escherichia coli O157: H7.

SE Dowd, JB Williams - Journal of food protection, 2008 - europepmc.org
The existence of two separate lineages of Escherichia coli O157: H7 has previously been
reported, and research indicates that one of these lineages (lineage I) might be more …