Simultaneous edited MRS of GABA and glutathione

MG Saleh, G Oeltzschner, KL Chan, NAJ Puts… - Neuroimage, 2016 - Elsevier
Edited MRS allows the detection of low-concentration metabolites, whose signals are not
resolved in the MR spectrum. Tailored acquisitions can be designed to detect, for example …

Multi-vendor standardized sequence for edited magnetic resonance spectroscopy

MG Saleh, D Rimbault, M Mikkelsen, G Oeltzschner… - Neuroimage, 2019 - Elsevier
Spectral editing allows direct measurement of low-concentration metabolites, such as GABA,
glutathione (GSH) and lactate (Lac), relevant for understanding brain (patho) physiology …

Simultaneous editing of GABA and GSH with Hadamard‐encoded MR spectroscopic imaging

KL Chan, G Oeltzschner, MG Saleh… - Magnetic resonance …, 2019 - Wiley Online Library
Purpose To evaluate the feasibility of simultaneous MR spectroscopic imaging (MRSI) of
gamma‐aminobutyric acid (GABA) and glutathione (GSH) in the human brain using …

Frequency and phase correction for multiplexed edited MRS of GABA and glutathione

M Mikkelsen, MG Saleh, J Near… - Magnetic resonance …, 2018 - Wiley Online Library
Purpose Detection of endogenous metabolites using multiplexed editing substantially
improves the efficiency of edited magnetic resonance spectroscopy. Multiplexed editing (ie …

Edited 1H magnetic resonance spectroscopy in vivo: Methods and metabolites

AD Harris, MG Saleh… - Magnetic resonance in …, 2017 - Wiley Online Library
The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …

Advanced Hadamard-encoded editing of seven low-concentration brain metabolites: Principles of HERCULES

G Oeltzschner, MG Saleh, D Rimbault, M Mikkelsen… - Neuroimage, 2019 - Elsevier
Purpose To demonstrate the framework of a novel Hadamard-encoded spectral editing
approach for simultaneously detecting multiple low-concentration brain metabolites in vivo …

An evaluation of the reproducibility of 1H-MRS GABA and GSH levels acquired in healthy volunteers with J-difference editing sequences at varying echo times

JJ Prisciandaro, M Mikkelsen, MG Saleh… - Magnetic resonance …, 2020 - Elsevier
Recent advances in J-difference-edited proton magnetic resonance spectroscopy (1 H MRS)
data acquisition and processing have led to the development of Hadamard Encoding and …

HERMES: Hadamard encoding and reconstruction of MEGA‐edited spectroscopy

KL Chan, NAJ Puts, M Schär, PB Barker… - Magnetic resonance …, 2016 - Wiley Online Library
Purpose To investigate a novel Hadamard‐encoded spectral editing scheme and evaluate
its performance in simultaneously quantifying N‐acetyl aspartate (NAA) and N‐acetyl …

Macromolecule‐suppressed GABA‐edited magnetic resonance spectroscopy at 3T

RAE Edden, NAJ Puts, PB Barker - Magnetic resonance in …, 2012 - Wiley Online Library
Edited magnetic resonance spectroscopy makes possible noninvasive studies of the role of
the inhibitory neurotransmitter GABA in the healthy brain and in disease processes. A major …

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil

KW Waddell, MJ Avison, JM Joers, JC Gore - Magnetic resonance imaging, 2007 - Elsevier
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in human brain and has
been implicated in several neuropsychiatric disorders. In vivo human brain GABA …