Primordial organisms of the putative RNA world would have required polymerase ribozymes
able to replicate RNA. Known ribozymes with polymerase activity best approximating that …

Early life presumably required polymerase ribozymes capable of replicating RNA. Known
polymerase ribozymes best approximating such replicases use as their catalytic engine an …

Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that
catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a …

The RNA-based organisms from which modern life is thought to have descended would
have depended on an RNA polymerase ribozyme to copy functional RNA molecules …

The class I ligase ribozyme catalyzes a Mg++-dependent RNA-ligation reaction that is
chemically analogous to a single step of RNA polymerization. Indeed, this ribozyme …

Life today is based on the “central dogma” of molecular biology, which describes how
genetic information is expressed as protein sequences. DNA information is copied into RNA …

Like most proteins, complex RNA molecules often are modular objects made up of distinct
structural and functional domains. The component domains of a protein can associate in …

The search is underway for a catalytic RNA molecule capable of self-replication. Finding
such a ribozyme would lend crucial support to the RNA World hypothesis, which holds that …

Seven families of RNA ligases, previously isolated from random RNA sequences, fall into
three classes on the basis of secondary structure and regiospecificity of ligation. Two of the …

The RNA-world hypothesis proposes that, before the advent of DNA and protein, life was
based on RNA, with RNA serving as both the repository of genetic information and the chief …