The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
NH Gehring, S Lamprinaki, MW Hentze… - PLoS biology, 2009 - journals.plos.org
Exon junction complexes (EJCs) link nuclear splicing to key features of mRNA function
including mRNA stability, translation, and localization. We analyzed the formation of EJCs by …
including mRNA stability, translation, and localization. We analyzed the formation of EJCs by …
Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay
A Alexandrov, D Colognori… - Proceedings of the …, 2012 - National Acad Sciences
The multiprotein exon junction complex (EJC) that is deposited upstream of spliced junctions
orchestrates downstream events in the life of a metazoan mRNA, including its surveillance …
orchestrates downstream events in the life of a metazoan mRNA, including its surveillance …
Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and-independent recruitment of exon junction complex components
Z Zhang, AR Krainer - … of the National Academy of Sciences, 2007 - National Acad Sciences
Pre-mRNA splicing not only removes introns and joins exons to generate spliced mRNA but
also results in remodeling of the spliced messenger ribonucleoprotein, influencing various …
also results in remodeling of the spliced messenger ribonucleoprotein, influencing various …
The exon junction complex as a node of post-transcriptional networks
HL Hir, J Saulière, Z Wang - Nature reviews Molecular cell biology, 2016 - nature.com
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …
eIF4A3 phosphorylation by CDKs affects NMD during the cell cycle
Exon junction complexes (EJCs) loaded onto spliced mRNAs during splicing serve as
molecular markers for various post-transcriptional gene-regulatory processes, including …
molecular markers for various post-transcriptional gene-regulatory processes, including …
Transcriptome-wide modulation of splicing by the exon junction complex
Z Wang, V Murigneux, H Le Hir - Genome biology, 2014 - Springer
Background The exon junction complex (EJC) is a dynamic multi-protein complex deposited
onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins …
onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins …
5′ exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly
VL Reichert, H Le Hir, MS Jurica… - Genes & …, 2002 - genesdev.cshlp.org
A general consequence of pre-mRNA splicing is the stable deposition of several proteins 20–
24 nucleotides (nt) upstream of exon–exon junctions on spliced mRNAs. This exon junction …
24 nucleotides (nt) upstream of exon–exon junctions on spliced mRNAs. This exon junction …
[HTML][HTML] EJCs at the heart of translational control
H Le Hir, B Séraphin - Cell, 2008 - cell.com
In mammalian cells, the splicing machinery deposits the exon junction complex (EJC) on
mRNA splice junctions. Two studies in this issue now link the EJC to different aspects of …
mRNA splice junctions. Two studies in this issue now link the EJC to different aspects of …
The exon junction complex controls the efficient and faithful splicing of a subset of transcripts involved in mitotic cell-cycle progression
K Fukumura, S Wakabayashi, N Kataoka… - International journal of …, 2016 - mdpi.com
The exon junction complex (EJC) that is deposited onto spliced mRNAs upstream of exon–
exon junctions plays important roles in multiple post-splicing gene expression events, such …
exon junctions plays important roles in multiple post-splicing gene expression events, such …
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly
I Barbosa, N Haque, F Fiorini, C Barrandon… - Nature structural & …, 2012 - nature.com
The exon-junction complex (EJC) functionally links splicing to subsequent mRNA
localization, translation and stability. Sequence-independent binding of the EJC core to RNA …
localization, translation and stability. Sequence-independent binding of the EJC core to RNA …