A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction
A Sivaraman, JK Leach, S Townsend… - Current drug …, 2005 - ingentaconnect.com
In vitro models of the liver using isolated primary hepatocytes have been used as screens for
measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte …
measuring the metabolism, toxicity and efficacy of xenobiotics, for studying hepatocyte …
Isolation and culture of primary human hepatocytes
EL LeCluyse, E Alexandre, GA Hamilton… - Basic Cell Culture …, 2005 - Springer
As our knowledge of the species differences in drug metabolism and drug-induced
hepatotoxicity has expanded significantly, the need for human-relevant in vitro hepatic …
hepatotoxicity has expanded significantly, the need for human-relevant in vitro hepatic …
General review on in vitro hepatocyte models and their applications
C Guguen-Guillouzo, A Guillouzo - Hepatocytes: methods and protocols, 2010 - Springer
In vitro hepatocyte models represent very useful systems in both fundamental research and
various application areas. Primary hepatocytes appear as the closest model for the liver in …
various application areas. Primary hepatocytes appear as the closest model for the liver in …
Isolation and culture of primary hepatocytes from resected human liver tissue
EL LeCluyse, E Alexandre - Hepatocytes: Methods and Protocols, 2010 - Springer
As our knowledge of the species differences in drug metabolism and drug-induced
hepatotoxicity has expanded significantly, the need for human-relevant in vitro hepatic …
hepatotoxicity has expanded significantly, the need for human-relevant in vitro hepatic …
Long-term culture of functional hepatocytes
A Guillouzo, F Morel, D Ratanasavanh, C Chesne… - Toxicology in vitro, 1990 - Elsevier
Recent studies have clearly demonstrated that the hepatocyte requires a complex and well
defined environment to survive and maintain differentiated functions in vitro. Soluble factors …
defined environment to survive and maintain differentiated functions in vitro. Soluble factors …
Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes
EL LeCluyse, PL Bullock, A Parkinson - Advanced Drug Delivery Reviews, 1996 - Elsevier
0169-409X/96/$32.00 0 1996 Elsevier Science BV All rights reserved PII SO169-409X (96)
00418-8 essential part of the drug development and discovery process 124.1 Xl …
00418-8 essential part of the drug development and discovery process 124.1 Xl …
[HTML][HTML] Bioengineered liver models for drug testing and cell differentiation studies
GH Underhill, SR Khetani - Cellular and molecular gastroenterology and …, 2018 - Elsevier
In vitro models of the human liver are important for the following:(1) mitigating the risk of drug-
induced liver injury to human beings,(2) modeling human liver diseases,(3) elucidating the …
induced liver injury to human beings,(2) modeling human liver diseases,(3) elucidating the …
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard …
R Gebhardt, JG Hengstler, D Müller… - Drug metabolism …, 2003 - Taylor & Francis
Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration …
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration …
Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures
G Elaut, T Henkens, P Papeleu… - Current drug …, 2006 - ingentaconnect.com
Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …
A human liver microphysiology platform for investigating physiology, drug safety, and disease models
LA Vernetti, N Senutovitch, R Boltz… - Experimental …, 2016 - journals.sagepub.com
This paper describes the development and characterization of a microphysiology platform
for drug safety and efficacy in liver models of disease that includes a human, 3D …
for drug safety and efficacy in liver models of disease that includes a human, 3D …