Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
Lung cancer remains one of the leading causes of cancer-related death in developed
countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions …
countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions …
[HTML][HTML] Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer
Background Squamous cell lung carcinomas account for approximately 25% of new lung
carcinoma cases and 40,000 deaths per year in the United States. Although there are …
carcinoma cases and 40,000 deaths per year in the United States. Although there are …
Cell-Autonomous and Non–Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer
F Malchers, F Dietlein, J Schöttle, X Lu, L Nogova… - Cancer discovery, 2014 - AACR
The 8p12 locus (containing the FGFR1 tyrosine kinase gene) is frequently amplified in
squamous cell lung cancer. However, it is currently unknown which of the 8p12-amplified …
squamous cell lung cancer. However, it is currently unknown which of the 8p12-amplified …
[HTML][HTML] Definition of a fluorescence in-situ hybridization score identifies high-and low-level FGFR1 amplification types in squamous cell lung cancer
HU Schildhaus, LC Heukamp, S Merkelbach-Bruse… - Modern …, 2012 - nature.com
We recently reported fibroblast growth factor receptor-type 1 (FGFR1) amplification to be
associated with therapeutically tractable FGFR1 dependency in squamous cell lung cancer …
associated with therapeutically tractable FGFR1 dependency in squamous cell lung cancer …
Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma
RG Liao, J Jung, J Tchaicha, MD Wilkerson… - Cancer research, 2013 - AACR
A comprehensive description of genomic alterations in lung squamous cell carcinoma (lung
SCC) has recently been reported, enabling the identification of genomic events that …
SCC) has recently been reported, enabling the identification of genomic events that …
[HTML][HTML] FGFR1 cooperates with EGFR in lung cancer oncogenesis, and their combined inhibition shows improved efficacy
A Quintanal-Villalonga, S Molina-Pinelo… - Journal of Thoracic …, 2019 - Elsevier
Introduction There is substantial evidence for the oncogenic effects of fibroblast growth factor
receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this …
receptor 1 (FGFR1) in many types of cancer, including lung cancer, but the role of this …
[HTML][HTML] FGFR1 amplification in squamous cell carcinoma of the lung
RS Heist, M Mino-Kenudson, LV Sequist… - Journal of thoracic …, 2012 - Elsevier
Introduction: Amplification of fibroblast growth factor receptor 1 (FGFR1) has been reported
in squamous cell lung carcinoma and may be a molecular target for therapy. Little is known …
in squamous cell lung carcinoma and may be a molecular target for therapy. Little is known …
FGFR1 mRNA and protein expression, not gene copy number, predict FGFR TKI sensitivity across all lung cancer histologies
MW Wynes, TK Hinz, D Gao, M Martini, LA Marek… - Clinical cancer …, 2014 - AACR
Purpose: FGFR1 gene copy number (GCN) is being evaluated as a biomarker for FGFR
tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive …
tyrosine kinase inhibitor (TKI) response in squamous cell lung cancers (SCC). The exclusive …
[HTML][HTML] Detection of known and novel FGFR fusions in non–small cell lung cancer by comprehensive genomic profiling
A Qin, A Johnson, JS Ross, VA Miller, SM Ali… - Journal of Thoracic …, 2019 - Elsevier
Introduction Activation of the fibroblast growth factor receptor (FGFR) family through fusion
with various partners has been described in multiple cancer types, including NSCLC. FGFR …
with various partners has been described in multiple cancer types, including NSCLC. FGFR …
Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non–Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models
J Zhang, L Zhang, X Su, M Li, L Xie, F Malchers… - Clinical Cancer …, 2012 - AACR
Purpose: To investigate the incidence of FGFR1 amplification in Chinese non–small cell
lung cancer (NSCLC) and to preclinically test the hypothesis that the novel, potent, and …
lung cancer (NSCLC) and to preclinically test the hypothesis that the novel, potent, and …