The RNA polymerase II transcription cycle is often divided into three major stages: initiation,
elongation, and termination. Research over the last decade has blurred these divisions and …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

While it has long been appreciated that regulation of transcription initiation is vital to sustain
dynamic gene expression, recent findings suggest that the control of transcription …

Termination of transcription by RNA polymerase II requires two distinct processes: The
formation of a defined 3′ end of the transcribed RNA, as well as the disengagement of RNA …

The pervasiveness of RNA synthesis in eukaryotes is largely the result of RNA polymerase II
(Pol II)-mediated transcription, and termination of its activity is necessary to partition the …

Abstract RNA polymerase II (Pol II) in Saccharomyces cerevisiae can terminate transcription
via several pathways. To study how a mechanism is chosen, we analyzed recruitment of …

In Saccharomyces cerevisiae, transcription termination at protein-coding genes is coupled to
the cleavage of the nascent transcript, whereas most non-coding RNA transcription relies on …

Most eukaryotic genes are transcribed by RNA polymerase II (Pol II), including those that
produce mRNAs and many noncoding functional RNAs. Proper expression of these genes …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Transcriptome studies on eukaryotic cells have revealed an unexpected abundance and
diversity of noncoding RNAs synthesized by RNA polymerase II (Pol II), some of which …