Recent and unambiguous evidences of the formation of DNA and RNA G-quadruplexes in
cells has provided solid support for these structures to be considered as valuable targets in …

Abstract G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the
promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s …

G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …

Conspectus Biomimetics is defined as a “practice of making technological design that copies
natural processes”, with the idea that “nature has already solved the challenges we are …

G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent
evidence points toward their existence in vivo and their implication in various biological …

G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …

Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …

An unprecedented strategy to control the quadruplex-vs duplex-DNA selectivity of a ligand is
reported. We designed a compound whose structure can rearrange when it interacts with a …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

Guanine rich DNA has been known for decades to form unusual structures, although their
biological relevance was little understood. Recent advances have demonstrated that …