Abstract Cyclobutane dipyrimidines and< 6-4> dipyrimidines are the two major classes of
mutagenic DNA photoproducts produced by UV irradiation of cells. We developed a method …

Protein-DNA interactions in mammalian cells can be analyzed at the nucleotide level of
resolution by genomic sequencing techniques. The most sensitive genomic sequencing …

Ultraviolet radiation activates the expression of a wide variety of genes, by pathways which
differ between the short non‐solar ultraviolet C (UVC) wavelengths, which are strongly …

The most prevalent DNA lesions induced by UVB are the cyclobutane pyrimidine dimers
(CPDs) and the pyrimidine (6-4) pyrimidone photoproducts ((6-4) PPs). It has been a long …

We used a simian virus 40-based shuttle vector plasmid, pZ189, to determine the role of
pyrimidine cyclobutane dimers in UV light-induced mutagenesis in monkey cells. The vector …

The mutagenic effects of ultraviolet and solar irradiation are thought to be due to the
formation of DNA photoproducts, most notably cyclobutane pyrimidine dimers (CPDs) and …

DNA adducts in unique sequences along the mammalian genome are mapped in vivo at
single-nucleotide resolution. Pyrimidine (6-4) pyrimidone photoproducts [(6-4) …

Irradiation of cells with short wave ultraviolet light (UV-C) induces both cyclobutane
pyrimidine dimers (CPD) as well as pyrimidine 6-4 pyrimidone photoproducts (6-4 PP). We …

The role of UV radiation-induced photoproducts in initiating base substitution mutations in
human cells was examined by measuring photoproduct frequency distributions and …

Bipyrimidine photoproducts induced in DNA by UVB radiation include cyclobutane dimers,(6-
4) photoproducts, and their related Dewar valence isomers. Even though these lesions have …