A highly conserved motif within the amelotin protein controls the surface growth of brushite

M Yu, L Wang, W Zhang, B Ganss - Crystal Growth & Design, 2018 - ACS Publications
Amelotin (AMTN) protein exerts a direct role on enamel biomineralization likely due to its
binding affinity with calcium phosphates (Ca-Ps). However, the kinetics and molecular …

An evolutionarily conserved subdomain in amelotin promotes amorphous calcium phosphate-to-hydroxyapatite phase transition

M Yu, L Wang, W Zhang, B Ganss - Crystal Growth & Design, 2019 - ACS Publications
Amelotin (AMTN) has been shown to promote hydroxyapatite (HAP) formation in the late
stages of tooth enamel biomineralization, but the molecular mechanisms that control this …

The enamel protein amelotin is a promoter of hydroxyapatite mineralization

N Abbarin, S San Miguel, J Holcroft… - Journal of Bone and …, 2015 - academic.oup.com
Amelotin (AMTN) is a recently discovered protein that is specifically expressed during the
maturation stage of dental enamel formation. It is localized at the interface between the …

Phosphorylated/nonphosphorylated motifs in amelotin turn off/on the acidic amorphous calcium phosphate-to-apatite phase transformation

J Zhang, L Wang, W Zhang, CV Putnis - Langmuir, 2020 - ACS Publications
Amelotin (AMTN) as a matrix protein exerts a direct effect on biomineralization by
modulating apatite (HAP) formation during the dental enamel maturation stage through the …

[HTML][HTML] Targeted overexpression of amelotin disrupts the microstructure of dental enamel

RS Lacruz, Y Nakayama, J Holcroft, V Nguyen… - PloS one, 2012 - journals.plos.org
We have previously identified amelotin (AMTN) as a novel protein expressed predominantly
during the late stages of dental enamel formation, but its role during amelogenesis remains …

Regulation of hydroxyapatite nucleation in vitro through ameloblastin–amelogenin interactions

C Shao, RA Bapat, J Su… - ACS biomaterials science …, 2022 - ACS Publications
Amelogenin (Amel) and ameloblastin (Ambn) are two primary extracellular enamel matrix
proteins that play crucial roles for proper thickness, prismatic structure, and robust …

Hydroxyapatite Growth on Amelogenin‐Amelotin Recombinamers

D Athanasiadou, AL Danesi, L Umbrio… - …, 2021 - Wiley Online Library
Strategies to improve hydroxyapatite mineralization for enamel repair are essential for tissue
regeneration. Amelogenin and amelotin (AMTN) are enamel matrix proteins playing critical …

Amelogenesis: Transformation of a protein-mineral matrix into tooth enamel

M Pandya, TGH Diekwisch - Journal of structural biology, 2021 - Elsevier
During enamel formation, the organic enamel protein matrix interacts with calcium
phosphate minerals to form elongated, parallel, and bundled enamel apatite crystals of …

Odontogenic ameloblast-associated protein (ODAM) and amelotin: Major players in hypermineralization of enamel and enameloid

K Kawasaki - Journal of Oral Biosciences, 2013 - Elsevier
Odontogenic ameloblast-associated protein (ODAM) and amelotin (AMTN) both belong to
the secretory calcium-binding phosphoprotein family, which is critical to biomineralization in …

The enamel protein ODAM promotes mineralization in a collagen matrix

Y Ikeda, M Neshatian, J Holcroft… - Connective Tissue …, 2018 - Taylor & Francis
Purpose/aim of the study: Odontogenic ameloblast-associated protein (ODAM) is
predominantly expressed during the maturation stage of enamel formation and interacts …