Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

A Abizaid, ZW Liu, ZB Andrews… - The Journal of …, 2006 - Am Soc Clin Investig
The gut hormone ghrelin targets the brain to promote food intake and adiposity. The ghrelin
receptor growth hormone secretagogue 1 receptor (GHSR) is present in hypothalamic …

Ghrelin directly targets the ventral tegmental area to increase food motivation

KP Skibicka, C Hansson, M Alvarez-Crespo, PA Friberg… - Neuroscience, 2011 - Elsevier
Ghrelin, a circulating orexigenic stomach-derived hormone, has recently been implicated in
extra-homeostatic feeding, increasing food reward and food-motivated behavior. The …

Ghrelin and dopamine: new insights on the peripheral regulation of appetite

A Abizaid - Journal of neuroendocrinology, 2009 - Wiley Online Library
A review is provided of current evidence supporting the actions of the stomach‐derived
peptide ghrelin on ventral tegmental area (VTA) dopamine cells to increase food intake and …

Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system

M Perello, SL Dickson - Journal of neuroendocrinology, 2015 - Wiley Online Library
'Hunger is the best spice'is an old and wise saying that acknowledges the fact that almost
any food tastes better when we are hungry. The neurobiological underpinnings of this lore …

Motivation to obtain preferred foods is enhanced by ghrelin in the ventral tegmental area

SJ King, AM Isaacs, E O'Farrell, A Abizaid - Hormones and behavior, 2011 - Elsevier
Ghrelin is an orexigenic peptide that acts within the central nervous system to stimulate
appetite and food intake via the growth hormone secretagogue receptor (GHS-R). It has …

[HTML][HTML] Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but …

KP Skibicka, RH Shirazi, C Rabasa-Papio… - …, 2013 - Elsevier
Obesity has reached global epidemic proportions and creating an urgent need to
understand mechanisms underlying excessive and uncontrolled food intake. Ghrelin, the …

Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens

AM Naleid, MK Grace, DE Cummings, AS Levine - Peptides, 2005 - Elsevier
Ghrelin, a powerful orexigenic peptide released from the gut, stimulates feeding when
injected centrally and has thus far been implicated in regulation of metabolic, rather than …

Preclinical study: ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus …

E Jerlhag, E Egecioglu, SL Dickson… - Addiction …, 2007 - Wiley Online Library
Ghrelin stimulates appetite, increases food intake and causes adiposity by mechanisms that
include direct actions on the brain. Previously, we showed that intracerebroventricular …

The central nervous system sites mediating the orexigenic actions of ghrelin

BL Mason, Q Wang, JM Zigman - Annual review of physiology, 2014 - annualreviews.org
The peptide hormone ghrelin is important for both homeostatic and hedonic eating
behaviors, and its orexigenic actions occur mainly via binding to the only known ghrelin …

Hyperphagic effects of brainstem ghrelin administration

LF Faulconbridge, DE Cummings, JM Kaplan… - Diabetes, 2003 - Am Diabetes Assoc
The role of ghrelin in feeding control has been addressed from a largely hypothalamic
perspective, with little attention directed at ingestive consequences of stimulation of the …