Nano-hydroxyapatite enhanced double network hydrogels with excellent mechanical properties for potential application in cartilage repair

S Gan, W Lin, Y Zou, B Xu, X Zhang, J Zhao… - Carbohydrate …, 2020 - Elsevier
Hydrogels with desirable characteristics have been supposed to be potential materials for
cartilage repair. However, the biomechanical, biotribological and biocompatible properties …

Physically cross-linked gellan gum/hydrophobically associated polyacrylamide double network hydrogel for cartilage repair

Y Wang, W Yu, S Liu - European Polymer Journal, 2022 - Elsevier
Biopolymer hydrogels have attracted much attention as scaffolds for tissue engineering
owing to the unique physical features analogous to native extracellular matrices. However …

Biomimetic bacterial cellulose-enhanced double-network hydrogel with excellent mechanical properties applied for the osteochondral defect repair

X Zhu, T Chen, B Feng, J Weng, K Duan… - ACS Biomaterials …, 2018 - ACS Publications
Although hydrogels based on biopolymers show many advantages, their low mechanical
properties limit their applications in osteochondral tissue engineering. In this study, one part …

Nanohydroxyapatite reinforced chitosan composite hydrogel with tunable mechanical and biological properties for cartilage regeneration

BYS Kumar, AM Isloor, GCM Kumar, Inamuddin… - Scientific Reports, 2019 - nature.com
With the continuous quest of developing hydrogel for cartilage regeneration with superior
mechanobiological properties are still becoming a challenge. Chitosan (CS) hydrogels are …

Double–network hydrogel based on exopolysaccharides as a biomimetic extracellular matrix to augment articular cartilage regeneration

Z Cai, Y Tang, Y Wei, P Wang, H Zhang - Acta Biomaterialia, 2022 - Elsevier
Cartilage regeneration remains a current challenge with no satisfactory strategy in surgery.
Hydrogels with structurally and biochemically biomimicking characteristics have been …

A tough polysaccharide-based cell-laden double-network hydrogel promotes articular cartilage tissue regeneration in rabbits

P Baei, H Daemi, F Mostafaei, FA Sayahpour… - Chemical Engineering …, 2021 - Elsevier
Hydrogels used for cartilage tissue engineering purposes must be designed to mimic the
biological and physical features of the native extracellular matrix (ECM). Here, we …

Double network hydrogel with high mechanical strength: Performance, progress and future perspective

YM Chen, K Dong, ZQ Liu, F Xu - Science China Technological Sciences, 2012 - Springer
With high water content (∼ 90 wt%) and significantly improved mechanical strength (∼
MPa), double network (DN) hydrogels have emerged as promising biomaterials with …

Injectable dual cross-linked adhesive hyaluronic acid multifunctional hydrogel scaffolds for potential applications in cartilage repair

C Yu, H Gao, Q Li, X Cao - Polymer Chemistry, 2020 - pubs.rsc.org
Injectable hydrogels have shown great potential for cartilage tissue engineering as three-
dimensional cell culture scaffolds, owing to their similarity to the extracellular matrix (ECM) …

A tough double network hydrogel for cartilage tissue engineering

C Fan, L Liao, C Zhang, L Liu - Journal of Materials Chemistry B, 2013 - pubs.rsc.org
To develop hydrogels with high mechanical strength for cell encapsulation and three-
dimensional culture is a critical challenge for cartilage tissue engineering. In this study …

Rapidly self-recoverable and fatigue-resistant hydrogels toughened by chemical crosslinking and hydrophobic association

X Liu, L Duan, G Gao - European Polymer Journal, 2017 - Elsevier
Designing load-bearing hydrogels with superior toughness and stiffness are crucially
important for cartilage replacement and tissue engineering. In this investigation, we report …