Background: The metabolic syndrome is a high-risk state for diabetes and cardiovascular
disease. Little is known about its prevalence and prevention in those with impaired glucose …

Background: The Diabetes Prevention Program (DPP) demonstrated that interventions can
delay or prevent the development of type 2 diabetes. Objective: To estimate the lifetime cost …

Background: Identifying reliable predictors of long-term weight loss (LTWL) could lead to
improved weight management. Objective: To identify some predictors of LTWL. Design: The …

This review describes the effect of lifestyle change or metformin compared with standard
care on incident type 2 diabetes and cardiometabolic risk factors in the Diabetes Prevention …

Background We investigated whether metformin hydrochloride has sustained beneficial
metabolic and (cardio) vascular effects in patients with type 2 diabetes mellitus (DM2) …

Background Type 2 diabetes affects approximately 8 percent of adults in the United States.
Some risk factors—elevated plasma glucose concentrations in the fasting state and after an …

Background: Lifestyle modification can forestall diabetes in high-risk people, but the long-
term cost-effectiveness is uncertain. Objective: To estimate the effects of the lifestyle …

Background: Lifestyle intervention and metformin have been shown to prevent diabetes;
however, their efficacy in preventing cardiovascular disease associated with the …

OBJECTIVE—The Diabetes Prevention Program demonstrated the ability to delay or prevent
type 2 diabetes in participants with impaired glucose tolerance (IGT). Participants with IGT …

OBJECTIVE To determine the effects of metformin on blood pressure, left ventricular mass,
and some metabolic and endocrine parameters in nondiabetic, obese, hypertensive women …