Tumor-infiltrating neoantigen-reactive T cells can mediate regression of metastatic
gastrointestinal cancers yet remain poorly characterized. We performed immunological …

Tumor-resident lymphocytes can mount a response against neoantigens expressed in
microsatellite-stable gastrointestinal (GI) cancers, and adoptive transfer of neoantigen …

CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite
instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of …

Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for
tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus …

Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been
correlated to poor prognosis and metastasis in multiple cancer types. However, the exact …

Pancreatic ductal adenocarcinoma (PDAC) is generally refractory to immune checkpoint
blockade, although patients with genetically unstable tumors can show modest therapeutic …

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform …

Immune evasion is a hallmark of cancer and therapies that restore immune surveillance
have proven highly effective in cancers with high tumor mutation burden (TMB)(for example …

Background Deciphering intra‐and inter‐tumoural heterogeneity is essential for
understanding the biology of gastric cancer (GC) and its metastasis and identifying effective …

Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy.
Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and …