[HTML][HTML] The functional organization of cutaneous low-threshold mechanosensory neurons

L Li, M Rutlin, VE Abraira, C Cassidy, L Kus, S Gong… - Cell, 2011 - cell.com
Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold
mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report …

Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors

ED Kuehn, S Meltzer, VE Abraira… - Proceedings of the …, 2019 - National Acad Sciences
Innocuous mechanical stimuli acting on the skin are detected by sensory neurons, known as
low-threshold mechanoreceptors (LTMRs). LTMRs are classified based on their response …

Genetic identification of an expansive mechanoreceptor sensitive to skin stroking

L Bai, BP Lehnert, J Liu, NL Neubarth… - Cell, 2015 - cell.com
Touch perception begins with activation of low-threshold mechanoreceptors (LTMRs) in the
periphery. LTMR terminals exhibit tremendous morphological heterogeneity that specifies …

The sensory neurons of touch

VE Abraira, DD Ginty - neuron, 2013 - cell.com
The somatosensory system decodes a wide range of tactile stimuli and thus endows us with
a remarkable capacity for object recognition, texture discrimination, sensory-motor feedback …

The cellular and molecular basis of direction selectivity of Aδ-LTMRs

M Rutlin, CY Ho, VE Abraira, C Cassidy, L Bai… - Cell, 2014 - cell.com
The perception of touch, including the direction of stimulus movement across the skin,
begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the …

The cellular and synaptic architecture of the mechanosensory dorsal horn

VE Abraira, ED Kuehn, AM Chirila, MW Springel… - Cell, 2017 - cell.com
The deep dorsal horn is a poorly characterized spinal cord region implicated in processing
low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic …

The mechanosensory neurons of touch and their mechanisms of activation

A Handler, DD Ginty - Nature Reviews Neuroscience, 2021 - nature.com
Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

The gentle touch receptors of mammalian skin

A Zimmerman, L Bai, DD Ginty - Science, 2014 - science.org
The skin is our largest sensory organ, transmitting pain, temperature, itch, and touch
information to the central nervous system. Touch sensations are conveyed by distinct …

Cortical responses to touch reflect subcortical integration of LTMR signals

AJ Emanuel, BP Lehnert, S Panzeri, CD Harvey… - Nature, 2021 - nature.com
Current models to explain how signals emanating from cutaneous mechanoreceptors
generate representations of touch are based on comparisons of the tactile responses of …

The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles

L Li, DD Ginty - Elife, 2014 - elifesciences.org
In mouse hairy skin, lanceolate complexes associated with three types of hair follicles,
guard, awl/auchene and zigzag, serve as mechanosensory end organs. These structures …