The unsatisfactory results of monoamine-based antidepressant therapy and the high
occurrence of somatic symptoms and physical illness in patients with depression imply that …

Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …

With the unsatisfaction of monoamine-based pharmacotherapy and the high comorbidity of
other medical illness in depression, the serotonin hypothesis seems to fail in approaching …

Depression is a common, recurrent, and debilitating illness that has become more prevalent
over the past 100 years. This report reviews the etiology and pathophysiology of depression …

Patients with depression have been extensively reported to be associated with the
abnormality of omega-3 polyunsaturated fatty acids (PUFAs), including significantly low …

The changing of omega‐6/omega‐3 polyunsaturated fatty acids (PUFA) in the food supply of
Western societies occurred over the last 150 years is thought to promote the pathogenesis of …

Brain lipids contain a high proportion of polyunsaturated fatty acids (PUFA), which are a
main component of cell membranes. Omega-3 (ω-3) PUFA eicosapentaeoic acid (EPA) and …

The central nervous system (CNS) has the highest concentration of lipids in the organism
after adipose tissue. Among these lipids, the brain is particularly enriched with …

Major depressive disorders (MDDs) are often associated with a deficiency in long-chain
omega-3 polyunsaturated fatty acids (ω-3 PUFAs), as well as signs of low-grade …

Increasing evidence suggests that inflammation responses play an important role in the
pathophysiology of depression. Clinically depressed patients manifest higher levels of …