Regional spreading pattern is associated with clinical phenotype in amyotrophic lateral sclerosis
Increasing evidence shows that disease spreading in amyotrophic lateral sclerosis (ALS)
follows a preferential pattern with more frequent involvement of contiguous regions from the …
follows a preferential pattern with more frequent involvement of contiguous regions from the …
Different patterns of spreading direction and motor neurons involvement in a cohort of limb‐onset amyotrophic lateral sclerosis patients from Southern Italy: Potential …
G Milella, S Zoccolella, D Urso, S Nigro… - Brain and …, 2023 - Wiley Online Library
Background Currently, there is a lack of knowledge concerning where the pathological
process starts and how the neurodegeneration spreads during the course of amyotrophic …
process starts and how the neurodegeneration spreads during the course of amyotrophic …
Spreading in ALS: The relative impact of upper and lower motor neuron involvement
M Gromicho, M Figueiral, H Uysal… - Annals of clinical …, 2020 - Wiley Online Library
Objective To investigate disease spread in amyotrophic lateral sclerosis (ALS), and
determine the influence of lower (LMN) and upper motor neuron (UMN) involvement …
determine the influence of lower (LMN) and upper motor neuron (UMN) involvement …
Regional spreading of symptoms at diagnosis as a prognostic marker in amyotrophic lateral sclerosis: a population-based study
Objective The lack of prognostic biomarkers in patients with amyotrophic lateral sclerosis
(ALS) induced researchers to develop clinical evaluation tools for stratification and survival …
(ALS) induced researchers to develop clinical evaluation tools for stratification and survival …
Onset and spreading patterns of upper and lower motor neuron symptoms in amyotrophic lateral sclerosis
S Körner, K Kollewe, M Fahlbusch, A Zapf… - Muscle & …, 2011 - Wiley Online Library
Introduction The potential linkage between upper (UMN) and lower motor neuron (LMN)
involvement in amyotrophic lateral sclerosis (ALS) has not yet been fully elucidated. There is …
involvement in amyotrophic lateral sclerosis (ALS) has not yet been fully elucidated. There is …
Study of motor asymmetry in ALS indicates an effect of limb dominance on onset and spread of weakness, and an important role for upper motor neurons
MS Devine, MC Kiernan, S Heggie… - … Lateral Sclerosis and …, 2014 - Taylor & Francis
In amyotrophic lateral sclerosis (ALS), onset and spread of upper motor neuron (UMN) and
lower motor neuron (LMN) dysfunction is typically asymmetric. Our aim was to investigate …
lower motor neuron (LMN) dysfunction is typically asymmetric. Our aim was to investigate …
Amyotrophic lateral sclerosis regional progression intervals change according to time of involvement of different body regions
U Manera, F D'Ovidio, S Cabras… - European Journal of …, 2023 - Wiley Online Library
Background and purpose The prediction of disease course is one of the main targets of
amyotrophic lateral sclerosis (ALS) research, particularly considering its wide phenotypic …
amyotrophic lateral sclerosis (ALS) research, particularly considering its wide phenotypic …
Early focality and spread of cortical dysfunction in amyotrophic lateral sclerosis: A regional study across the motor cortices
T Dharmadasa, JM Matamala, J Howells, S Vucic… - Clinical …, 2020 - Elsevier
Objective To characterise the regional cortical patterns underlying clinical symptomatology
in amyotrophic lateral sclerosis (ALS). Methods 138 patients prospectively underwent …
in amyotrophic lateral sclerosis (ALS). Methods 138 patients prospectively underwent …
Longitudinal course of cortical thickness decline in amyotrophic lateral sclerosis
C Schuster, E Kasper, J Machts, D Bittner… - Journal of …, 2014 - Springer
To determine longitudinal rates of cortical atrophy in classical Amyotrophic lateral sclerosis
(ALS) and ALS variants. Rates of cortical thinning were determined between 2 scans, 3–15 …
(ALS) and ALS variants. Rates of cortical thinning were determined between 2 scans, 3–15 …
Uncovering amyotrophic lateral sclerosis phenotypes: clinical features and long-term follow-up of upper motor neuron-dominant ALS
M Sabatelli, M Zollino, M Luigetti… - Amyotrophic Lateral …, 2011 - Taylor & Francis
The aim of our study was to analyse the natural history and clinical features of upper motor
neuron-dominant (UMN-D) ALS. We studied a large series of sporadic ALS patients …
neuron-dominant (UMN-D) ALS. We studied a large series of sporadic ALS patients …