Exosome Therapy: A Novel Approach for Enhancing Estrogen Levels in Perimenopause

S Alkhrait, MM Omran, MM Ghasroldasht… - International Journal of …, 2024 - mdpi.com
Perimenopause significantly impacts women's health globally, often managed with hormone
replacement therapy (HRT) despite the associated risks. This study explores a novel …

[HTML][HTML] Exosome therapy in female reproductive aging

M Zhang, S Zhang, S Wang - Extracellular Vesicle, 2024 - Elsevier
As life expectancy continues to extend, the adverse effects of reproductive aging on female
health have become progressively conspicuous. Despite the extant focus on symptom …

Human umbilical cord mesenchymal stem cell‑derived exosomes improve ovarian function in natural aging by inhibiting apoptosis

Z Li, Y Liu, Y Tian, Q Li, W Shi… - International …, 2023 - spandidos-publications.com
Prolonging the reproductive lifespan is beneficial for preserving the physical and
psychological health of women. The transplantation of mesenchymal stem cell (MSC) …

Promising effects of exosomes from menstrual blood-derived mesenchymal stem cells on endometriosis

FD Asl, SS Sahraei, N Kalhor, H Fazaeli… - Reproductive …, 2023 - Elsevier
Endometriosis as a non-malignant gynecological disease leads to dysregulation of
numerous cellular functions including apoptosis, angiogenesis, migration, proliferation, and …

Human umbilical cord mesenchymal stem cell-derived exosomes improve ovarian function and proliferation of premature ovarian insufficiency by regulating the hippo …

Z Li, M Zhang, J Zheng, Y Tian, H Zhang… - Frontiers in …, 2021 - frontiersin.org
Background Premature ovarian insufficiency (POI) is associated with severe physical
damage and psychological burden on women. Transplantation of exosomes is an …

[HTML][HTML] Menstrual Blood Stem Cells-Derived Exosomes as Promising Therapeutic Tools in Premature Ovarian Insufficiency Induced by Gonadotoxic Systemic …

M Robalo Cordeiro, R Roque, B Laranjeiro… - International Journal of …, 2024 - mdpi.com
Gonadotoxicity resulting from systemic and locoregional cancer treatments significantly
threatens women's reproductive health, often culminating in premature ovarian insufficiency …

[HTML][HTML] Delivering umbilical cord mesenchymal stem cell exosomes through hydrogel ameliorates vaginal atrophy in ovariectomized rats

T Zhang, D Li, Y Wang, C Zhang, W Yang… - Aging (Albany NY …, 2023 - ncbi.nlm.nih.gov
Background: Menopausal and postmenopausal women often experience vaginal atrophy
due to estrogen deficiency. Mesenchymal stem cell exosomes have emerged as potential …

Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring microRNAs against apoptosis

Q Zhang, J Sun, Y Huang, S Bu, Y Guo, T Gu… - … Therapy-Nucleic Acids, 2019 - cell.com
Premature ovarian failure (POF) is one of the most common complications among female
patients with tumors treated with chemotherapy and requires advanced treatment strategies …

A Comparative Analysis of Naïve Exosomes and Enhanced Exosomes with a Focus on the Treatment Potential in Ovarian Disorders

M Mousaei Ghasroldasht, F Liakath Ali… - Journal of Personalized …, 2024 - mdpi.com
Exosome-based therapy has emerged as a promising strategy for addressing diverse
disorders, indicating the need for further exploration of the potential therapeutic effects of the …

Exosomes and female infertility

X Sun, X Ma, X Yang, X Zhang - Current drug metabolism, 2019 - ingentaconnect.com
Background: Exosomes are small Extracellular Vesicles (EVs)(40-100 nm) secreted by living
cells and mediate the transmission of information between cells. The number and contents …