Objective To assess the structural correlates of cognitive and behavioral impairment in motor
neuron diseases (MND) using multimodal MRI. Methods One hundred one patients with …

Purpose To investigate the patterns of cortical thinning and white matter tract damage in
patients with lower motor neuron (LMN)–predominant disease compared with healthy …

This prospective study developed an MRI-based method for identification of individual motor
neuron disease (MND) patients and test its accuracy at the individual patient level in an …

The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients
show structural changes within but also beyond the motor cortex and corticospinal tract and …

Using diffusion tensor (DT) magnetic resonance imaging (MRI), damage to brain
intrahemispheric and interhemispheric connections was assessed in 26 sporadic primary …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Objective To discern presymptomatic changes in brain structure or function using advanced
MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). Methods T1 …

BACKGROUND AND PURPOSE: ALS is predominantly a disease of the motor system, but
cognitive and behavioral symptoms also are observed. DT MR imaging is sensitive to …

Amyotrophic lateral sclerosis as a system failure is a concept supported by the finding of
consistent extramotor as well as motor cerebral pathology. The functional correlates of the …

Amyotrophic lateral sclerosis (ALS) is a progressive and intractable neurodegenerative
disease of human motor system characterized by progressive muscular weakness and …