The timing of puberty is a highly polygenic childhood trait that is epidemiologically
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes …

Pubertal timing varies considerably and is associated with later health outcomes. We
performed multi-ancestry genetic analyses on~ 800,000 women, identifying 1,080 signals for …

Age at menarche and age at natural menopause are associated with causes of substantial
morbidity and mortality such as breast cancer and cardiovascular disease. We conducted a …

Little is known about genes regulating male puberty. Further, while many identified pubertal
timing variants associate with age at menarche, a late manifestation of puberty, and body …

The timing of puberty is highly variable and is associated with long-term health outcomes. To
date, understanding of the genetic control of puberty timing is based largely on studies in …

We conducted a meta-analysis of genome-wide association data to detect genes influencing
age at menarche in 17,510 women. The strongest signal was at 9q31. 2 (P= 1.7× 10− 9) …

The timing of puberty is highly variable. We carried out a genome-wide association study for
age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 …

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both
the central onset of puberty and local growth factors. Although little is known about the …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy …