Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …

Tissue-engineered constructs, at the interface of material science, biology, engineering, and
medicine, have the capacity to improve outcomes for cardiac patients by providing living …

A significant challenge in cardiac tissue engineering is the development of biomimetic grafts
that can potentially promote myocardial repair and regeneration. A number of approaches …

We demonstrate here a cardiac tissue-engineering strategy addressing multicellular
organization, integration into host myocardium, and directional cues to reconstruct the …

In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create
functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular …

There has been considerable progress in engineering cardiac scaffolds for the treatment of
myocardial infarction (MI). However, it is still challenging to replicate the structural specificity …

For patients with end-stage heart disease, the access to heart transplantation is limited due
to the shortage of donor organs and to the potential for rejection of the donated organ …

Despite great progress in engineering functional tissues for organ repair, including the heart,
an invasive surgical approach is still required for their implantation. Here, we designed an …

Extracellular matrix (ECM) structure and biochemistry provide cell-instructive cues that
promote and regulate tissue growth, function, and repair. From a structural perspective, the …

The ability to control the degree of structural and functional anisotropy in 3D engineered
cardiac tissues would have high utility for both in vitro studies of cardiac muscle physiology …