There is growing interest in communicating clinically relevant DNA sequence findings to
research participants who join projects with a primary research goal other than the clinical …

Background Increasing numbers of healthy individuals are undergoing predispositional
personal genome sequencing. Here we describe the design and early outcomes of the …

Background Whole genome sequencing (WGS) is already being used in certain clinical and
research settings, but its impact on patient well-being, health-care utilization, and clinical …

The advancement of precision medicine requires new methods to coordinate and deliver
genetic data from heterogeneous sources to physicians and patients. The eMERGE III …

As more research studies incorporate next-generation sequencing (including whole-
genome or whole-exome sequencing), investigators and institutional review boards face …

Although the potential for genomics to contribute to clinical care has long been anticipated,
the pace of defining the risks and benefits of incorporating genomic findings into medical …

The introduction of clinical genome‐wide sequencing raises complex issues regarding the
management of incidental findings. However, there is a lack of empirical studies assessing …

Background Population-based genomic screening has the predicted ability to reduce
morbidity and mortality associated with medically actionable conditions. However, much …

Rapid advances in DNA sequencing promise to enable new diagnostics and individualized
therapies. Achieving personalized medicine, however, will require extensive research on …

The pace of exome and genome sequencing is accelerating, with the identification of many
new disease-causing mutations in research settings, and it is likely that whole exome or …