There is growing consensus that intervention and treatment of Huntington disease (HD)
should occur at the earliest stage possible. Various early-intervention methods for this fatal …

Participants with the gene expansion for Huntington disease (HD) but not yet diagnosed
were evaluated annually. Unidimensional diagnosis (UD) was a motor diagnosis defined as …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Background TRACK-HD is a prospective observational study of Huntington's disease (HD)
that examines disease progression in premanifest individuals carrying the mutant HTT gene …

Background Huntington's disease (HD) is an autosomal dominant, fully penetrant,
neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to …

Background Disease-modifying treatments are in development for Huntington's disease;
crucial to their success is to identify a timepoint in a patient's life when there is a measurable …

Objective: The objective of the Predict-HD study is to use genetic, neurobiological and
refined clinical markers to understand the early progression of Huntington's disease (HD) …

Background and objective Controversy exists regarding the feasibility of preventive clinical
trials in prodromal Huntington disease (HD). A primary limitation is a lack of outcome …

Background TRACK-HD is a multinational prospective observational study of Huntington's
disease (HD) that examines clinical and biological findings of disease progression in …

Background TRACK-HD is a prospective observational biomarker study in premanifest and
early Huntington's disease (HD). In this report we define a battery of potential outcome …