The final step of cytoplasmic mRNA degradation proceeds in either a 5′‐3′ direction
catalysed by Xrn1 or in a 3′‐5′ direction catalysed by the exosome. Dis3/Rrp44, an …

The exosome is an exoribonuclease complex involved in the degradation and maturation of
a wide variety of RNAs. The nine‐subunit core of the eukaryotic exosome is catalytically …

Turnover of mRNA in the cytoplasm of human cells is thought to be redundantly conducted
by the monomeric 5′‐3′ exoribonuclease hXRN1 and the 3′‐5′ exoribonucleolytic …

The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and
turnover. It consists of a nine‐subunit catalytically inert core that serves a structural function …

The eukaryotic exosome is a ten-subunit 3′ exoribonucleolytic complex responsible for
many RNA-processing and RNA-degradation reactions. How the exosome accomplishes …

The RNA processing exosome complex was originally defined as an evolutionarily
conserved multisubunit complex of ribonucleases responsible for the processing and/or …

The RNA exosome processes and degrades RNAs in archaeal and eukaryotic cells.
Exosomes from yeast and humans contain two active exoribonuclease components, Rrp6p …

The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA
degradation as a critical component of the major decaysome. Its deletion in the yeast …

The exosome, an evolutionarily conserved complex of multiple 3′→ 5′ exoribonucleases,
is responsible for a variety of RNA processing and degradation events in eukaryotes. In this …

The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …