STLV-1 Commonly targets neurons in the brain of asymptomatic non-human primates

B Rocamonde, S Alais, R Pelissier, V Moulin… - Mbio, 2023 - Am Soc Microbiol
The human T-cell leukemia virus (HTLV)-1 is responsible for an aggressive
neurodegenerative disease (HAM/TSP) and multiple neurological alterations. The capacity …

HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells …

ES Gudo, SD Silva-Barbosa, L Linhares-Lacerda… - Virology Journal, 2015 - Springer
Background The mechanisms through which HTLV-1 leads to and maintains damage in the
central nervous system of patients undergoing HTLV-1 associated myelopathy/tropical …

[HTML][HTML] Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease

V Lepoutre, P Jain, K Quann, B Wigdahl… - Frontiers in bioscience …, 2009 - ncbi.nlm.nih.gov
Human T cell leukemia virus type 1 (HTLV-1) is a type C retrovirus primarily endemic to
Japan, Central and South America, the Middle East, regions of Africa, and the Caribbean (1 …

HTLV-1 induces a Th1-like state in CD4+ CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP

Y Yamano, A Coler-Reilly - Journal of neuroimmunology, 2017 - Elsevier
The main feature of Human T-lymphotropic virus type I (HTLV-1)-associated
myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis is a virus-induced …

HTLV-1 infection of myeloid cells: from transmission to immune alterations

B Rocamonde, A Carcone, R Mahieux, H Dutartre - Retrovirology, 2019 - Springer
Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell
leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as …

[HTML][HTML] Identification and tracking of HTLV-1–infected T cell clones in virus-associated neurologic disease

S Nozuma, E Matsuura, M Tanaka, D Kodama… - JCI insight, 2023 - ncbi.nlm.nih.gov
Human T lymphotropic virus type 1–assoicated (HTLV-1–associated) myelopathy/tropical
spastic paraparesis (HAM/TSP) is a neuroinflammatory disease caused by the persistent …

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice

R Ginwala, B Caruso, ZK Khan, A Pattekar… - Journal of Neuroimmune …, 2017 - Springer
To date, the lack of a suitable small animal model has hindered our understanding of
Human T-cell lymphotropic virus (HTLV)-1 chronic infection and associated …

Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder

Y Yamano, N Araya, T Sato, A Utsunomiya, K Azakami… - PloS one, 2009 - journals.plos.org
Background Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus associated
with both HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is a …

Cytokine networks dysregulation during HTLV-1 infection and associated diseases

N Futsch, G Prates, R Mahieux, J Casseb, H Dutartre - Viruses, 2018 - mdpi.com
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of a neural chronic
inflammation, called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

A new hypothesis for the pathogenesis of Human T-lymphotropic virus type 1 associated myelopathy/tropical spastic paraparesis

AJ Mosley, CRM Bangham - Bioscience Hypotheses, 2009 - Elsevier
The exogenous, human retrovirus Human T-lymphotropic virus type 1 (HTLV-1) results in a
highly dynamic persistent infection. HTLV-1 usually causes an asymptomatic infection but a …