A trade-off between the fitness cost of functional integrases and long-term stability of integrons

I Starikova, K Harms, P Haugen, TTM Lunde… - PLoS …, 2012 - journals.plos.org
Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from
the rapid emergence and spread of antimicrobial drug resistance. Few studies have …

The evolutionary dynamics of integrons in changing environments

J Engelstädter, K Harms, PJ Johnsen - The ISME journal, 2016 - academic.oup.com
Integrons are genetic elements that are common in bacteria and are hotspots for genome
evolution. They facilitate the acquisition and reassembly of gene cassettes encoding a …

Gene expression in class 2 integrons is SOS-independent and involves two Pc promoters

T Jové, S Da Re, A Tabesse, A Gassama-Sow… - Frontiers in …, 2017 - frontiersin.org
Integrons are powerful bacterial genetic elements that permit the expression and
dissemination of antibiotic-resistance gene cassettes. They contain a promoter Pc that …

An analysis of the evolutionary relationships of integron integrases, with emphasis on the prevalence of class 1 integrons in Escherichia coli isolates from clinical and …

JJ Diaz-Mejia, CF Amabile-Cuevas, I Rosas… - …, 2008 - microbiologyresearch.org
Integrons are genetic elements that allow the mobilization and expression of smaller
elements called gene cassettes, and are considered to be key elements in the evolution of …

Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons

G Cambray, N Sanchez-Alberola, S Campoy, É Guerin… - Mobile DNA, 2011 - Springer
Background Integrons are found in hundreds of environmental bacterial species, but are
mainly known as the agents responsible for the capture and spread of antibiotic-resistance …

Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure

C Souque, JA Escudero, RC MacLean - MBio, 2023 - Am Soc Microbiol
Integrons are mobile genetic elements that have played an important role in the
dissemination of antibiotic resistance. Under stress, the integron can generate combinatorial …

The natural history of integrons

TM Ghaly, MR Gillings, A Penesyan, Q Qi, V Rajabal… - Microorganisms, 2021 - mdpi.com
Integrons were first identified because of their central role in assembling and disseminating
antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically …

High-level gene cassette transcription prevents integrase expression in class 1 integrons

E Guérin, T Jové, A Tabesse, D Mazel… - Journal of …, 2011 - Am Soc Microbiol
Class 1 integrons are widespread genetic elements responsible for dissemination of
antibiotic resistance among Gram-negative bacteria. Integrons allow bacteria to capture and …

Environmental integrons: The dark side of the integron world

E Sandoval-Quintana, B Lauga, C Cagnon - Trends in Microbiology, 2023 - cell.com
Integrons are bacterial genetic elements notorious for their role in spreading antibiotic
resistance in clinical settings. In the natural environment, integrons present a wide and …

Integrons: vehicles and pathways for horizontal dissemination in bacteria

S Domingues, GJ da Silva, KM Nielsen - Mobile genetic elements, 2012 - Taylor & Francis
Integrons are genetic elements first described at the end of the 1980s. Although most
integrons were initially described in human clinical isolates, they have now been identified …