A trade-off between the fitness cost of functional integrases and long-term stability of integrons
I Starikova, K Harms, P Haugen, TTM Lunde… - PLoS …, 2012 - journals.plos.org
Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from
the rapid emergence and spread of antimicrobial drug resistance. Few studies have …
the rapid emergence and spread of antimicrobial drug resistance. Few studies have …
The evolutionary dynamics of integrons in changing environments
Integrons are genetic elements that are common in bacteria and are hotspots for genome
evolution. They facilitate the acquisition and reassembly of gene cassettes encoding a …
evolution. They facilitate the acquisition and reassembly of gene cassettes encoding a …
Gene expression in class 2 integrons is SOS-independent and involves two Pc promoters
T Jové, S Da Re, A Tabesse, A Gassama-Sow… - Frontiers in …, 2017 - frontiersin.org
Integrons are powerful bacterial genetic elements that permit the expression and
dissemination of antibiotic-resistance gene cassettes. They contain a promoter Pc that …
dissemination of antibiotic-resistance gene cassettes. They contain a promoter Pc that …
An analysis of the evolutionary relationships of integron integrases, with emphasis on the prevalence of class 1 integrons in Escherichia coli isolates from clinical and …
JJ Diaz-Mejia, CF Amabile-Cuevas, I Rosas… - …, 2008 - microbiologyresearch.org
Integrons are genetic elements that allow the mobilization and expression of smaller
elements called gene cassettes, and are considered to be key elements in the evolution of …
elements called gene cassettes, and are considered to be key elements in the evolution of …
Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons
Background Integrons are found in hundreds of environmental bacterial species, but are
mainly known as the agents responsible for the capture and spread of antibiotic-resistance …
mainly known as the agents responsible for the capture and spread of antibiotic-resistance …
Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
Integrons are mobile genetic elements that have played an important role in the
dissemination of antibiotic resistance. Under stress, the integron can generate combinatorial …
dissemination of antibiotic resistance. Under stress, the integron can generate combinatorial …
The natural history of integrons
Integrons were first identified because of their central role in assembling and disseminating
antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically …
antibiotic resistance genes in commensal and pathogenic bacteria. However, these clinically …
High-level gene cassette transcription prevents integrase expression in class 1 integrons
E Guérin, T Jové, A Tabesse, D Mazel… - Journal of …, 2011 - Am Soc Microbiol
Class 1 integrons are widespread genetic elements responsible for dissemination of
antibiotic resistance among Gram-negative bacteria. Integrons allow bacteria to capture and …
antibiotic resistance among Gram-negative bacteria. Integrons allow bacteria to capture and …
Environmental integrons: The dark side of the integron world
E Sandoval-Quintana, B Lauga, C Cagnon - Trends in Microbiology, 2023 - cell.com
Integrons are bacterial genetic elements notorious for their role in spreading antibiotic
resistance in clinical settings. In the natural environment, integrons present a wide and …
resistance in clinical settings. In the natural environment, integrons present a wide and …
Integrons: vehicles and pathways for horizontal dissemination in bacteria
S Domingues, GJ da Silva, KM Nielsen - Mobile genetic elements, 2012 - Taylor & Francis
Integrons are genetic elements first described at the end of the 1980s. Although most
integrons were initially described in human clinical isolates, they have now been identified …
integrons were initially described in human clinical isolates, they have now been identified …