Background Treatment in bipolar disorder (BD) is commonly applied as a multimodal
therapy based on decision algorithms that lack an integrative understanding of molecular …

Bipolar disorder (BD) is a lifelong severe psychiatric condition with high morbidity, disability
and excess mortality. The longitudinal clinical trajectory of BD is significantly modified by …

Background Bipolar disorder (BD) is a psychiatric illness defined by pathological alterations
between the mood states of mania and depression, causing disability, imposing healthcare …

The hopes for readily implementable precision medicine are high. For many complex
disorders, such as bipolar disorder, these hopes critically hinge on tangible successes in …

The holistic approach of personalized medicine, merging clinical and molecular
characteristics to tailor the diagnostic and therapeutic path to each individual, is steadily …

This is a personal perspective on bipolar disorder, entirely written by a well-informed patient
who is a successful mental heath professional. The patient prefers to remain anonymous; …

Objective Due to the phenotypic heterogeneity and etiological complexity of bipolar disorder
(BD), many patients do not respond well to the current medications, and developing novel …

Bipolar disorder (BD) is a common and disabling psychiatric condition with a severe
socioeconomic impact. BD is treated with mood stabilizers, among which lithium represents …

BACKGROUND: Bipolar disorder is a frequent cause of disability and healthcare costs.
Variability in outcome leads to a large number of treatment failures, typically followed by a …

Bipolar disorder (BD) is a chronic and often severe psychiatric illness characterized by
manic and depressive episodes. Among the most effective treatments, mood stabilizers …