Caloric restriction is known to improve inflammatory and autoimmune diseases. However,
the mechanisms by which reduced caloric intake modulates inflammation are poorly …

Diet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via
its influence on immunity and metabolism, caloric restriction and fasting appear to be …

As humans evolved, perhaps the two strongest selection determinants of survival were a
robust immune response able to clear bacterial, viral, and parasitic infection and an ability to …

Integrated immunometabolic responses link dietary intake, energy utilization, and storage to
immune regulation of tissue function and is therefore essential for the maintenance and …

Fasting metabolism and immunity are tightly linked; however, it is largely unknown how
immune cells contribute to metabolic homeostasis during fasting in healthy subjects. Here …

Immune cell function and metabolism are closely linked. Many studies have now clearly
demonstrated that alterations in cellular metabolism influence immune cell function and that …

Highly ordered interactions between immune and metabolic responses are evolutionarily
conserved and paramount for tissue and organismal health. Disruption of these interactions …

Obesity arises from a sustained positive energy balance which triggers a pro-inflammatory
response, a key contributor to metabolic diseases such as T2D. Recent studies, focused on …

Nutrition is essential for supplying an organism with sufficient energy to maintain its bodily
functions. Apart from serving as an energy supply, the immunomodulatory effects of diet are …

Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of
health issues and inflammatory diseases in modern society. The balance between energy …