RNA-based viral immunity (RVI) operates in fungi, plants, and invertebrates to specifically
destroy viral RNAs using the cellular RNA interference machinery. Discovery of diverse viral …

RNA silencing is a fundamental, evolutionarily conserved mechanism that regulates gene
expression in eukaryotes. It also functions as a primary immune defense in microbes, such …

Plants and invertebrates can protect themselves from viral infection through RNA silencing.
This antiviral immunity involves production of virus-derived small interfering RNAs (viRNAs) …

Viruses are obligate, intracellular pathogens that must manipulate and exploit host
molecular mechanisms to prosper in the hostile cellular environment. Here we review the …

Pathogenic viruses have developed a molecular defense arsenal for their survival by
counteracting the host anti-viral system known as RNA interference (RNAi). Cellular RNAi, in …

Highlights•Factors of RNA viruses enters into host nucleus to facilitate viral infection.•The
VSRs of RNA virus that replicates in cytoplasm suppress host TGS.•The suppression action …

RNA silencing plays a critical role in plant resistance against viruses, with multiple silencing
factors participating in antiviral defense. Both RNA and DNA viruses are targeted by the …

The infection and replication of viruses in the host induce diverse mechanisms for combating
viral infection. One of the best-studied antiviral defence mechanisms is based on RNA …

RNA silencing is a novel RNA-guided gene regulatory mechanism operational in a wide
range of eukaryotic organisms from fission yeast, plants, to mammals. This article reviews …

In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a
pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) …